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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2023-03-31]	SOLE	0.0	8,263,982.0
Sofinnova Investments Inc	[2023-03-31]	SOLE	3,758,686.0	3,758,686.0
Atlas Venture Life Science Advisors LLC	[2023-03-31]	SOLE	2,039,249.0	2,039,249.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	1,963,479.0	1,963,479.0
Cormorant Asset Management LP	[2023-03-31]	DFND	1,561,696.0	1,561,696.0
TCG Crossover Management LLC	[2023-03-31]	SOLE	1,081,274.0	1,081,274.0
VR Adviser LLC	[2023-03-31]	SOLE	833,927.0	833,927.0
OrbiMed Advisors LLC	[2023-03-31]	DFND	215,100.0	756,930.0
Great Point Partners LLC	[2023-03-31]	DFND	0.0	755,620.0
Octagon Capital Advisors LP	[2023-03-31]	SOLE	621,712.0	621,712.0
OUP Management Co LLC	[2023-03-31]	SOLE	603,762.0	603,762.0
BlackRock Inc.	[2023-03-31]	SOLE	587,175.0	599,999.0
FMR LLC	[2023-03-31]	DFND	570,180.0	570,965.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	498,357.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	338,110.0	338,110.0
Ghost Tree Capital LLC	[2023-03-31]	SOLE	200,000.0	200,000.0
Ikarian Capital LLC	[2023-03-31]	SOLE	195,146.0	195,146.0
Geode Capital Management LLC	[2023-03-31]	DFND	187,499.0	187,499.0
State Street Corp	[2023-03-31]	DFND	172,993.0	184,593.0
Fred Alger Management LLC	[2023-03-31]	SOLE	104,048.0	104,048.0
Nantahala Capital Management LLC	[2023-03-31]	SOLE	95,000.0	95,000.0
Northern Trust Corp	[2023-03-31]	DFND	798.0	77,439.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	69,119.0
Skandinaviska Enskilda Banken AB (publ)	[2023-03-31]	DFND	0.0	50,866.0
Eversept Partners LP	[2023-03-31]	SOLE	50,242.0	50,242.0
Nan Fung Group Holdings Ltd	[2023-03-31]	DFND	47,936.0	47,936.0
Morgan Stanley	[2023-03-31]	DFND	44,794.0	44,974.0
Boothbay Fund Management LLC	[2023-03-31]	OTR	0.0	39,573.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	36,310.0	36,310.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	23,876.0	27,795.0
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