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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
CPMG Inc	[2023-03-31]	SOLE	2,896,901.0	2,896,901.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,678,532.0
BlackRock Inc.	[2023-03-31]	SOLE	2,170,229.0	2,209,548.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	2,169,276.0	2,169,276.0
First Light Asset Management LLC	[2023-03-31]	SOLE	1,586,928.0	1,586,928.0
Deutsche Bank AG	[2023-03-31]	DFND	1,480,253.0	1,494,877.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	1,421,162.0
Boxer Capital, LLC	[2023-03-31]	OTR	1,230,004.0	1,230,004.0
Susquehanna International Group LLP	[2023-03-31]	DFND	101,870.0	947,070.0
Deep Track Capital LP	[2023-03-31]	SOLE	729,000.0	729,000.0
State Street Corp	[2023-03-31]	DFND	569,742.0	632,945.0
Caption Management LLC	[2023-03-31]	SOLE	630,100.0	630,100.0
Sofinnova Investments Inc	[2023-03-31]	SOLE	627,683.0	627,683.0
Geode Capital Management LLC	[2023-03-31]	DFND	549,313.0	549,313.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	469,618.0	469,618.0
Bank of America Corp /DE/	[2023-03-31]	DFND	59,633.0	428,096.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	414,954.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	403,556.0
Ghost Tree Capital LLC	[2023-03-31]	SOLE	370,000.0	370,000.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	364,100.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	347,961.0	347,961.0
Blackstone Inc.	[2023-03-31]	OTR	0.0	340,793.0
Citadel Advisors LLC	[2023-03-31]	DFND	327,307.0	327,307.0
Farallon Capital Management LLC	[2023-03-31]	OTR	325,000.0	325,000.0
Emerald Advisers LLC	[2023-03-31]	SOLE	230,519.0	314,621.0
Braun Stacey Associates Inc	[2023-03-31]	DFND	251,977.0	311,010.0
Holocene Advisors LP	[2023-03-31]	SOLE	304,725.0	304,725.0
Northern Trust Corp	[2023-03-31]	DFND	24,455.0	282,442.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	52,486.0	281,416.0
Emerald Mutual Fund Advisers Trust	[2023-03-31]	SOLE	255,018.0	255,018.0
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