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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Decheng Capital LLC	[2025-06-30]	SOLE	3,917,299	3,917,299
Citadel Advisors LLC	[2025-06-30]	DFND	1,283,732	1,283,732
Laurion Capital Management LP	[2025-06-30]	SOLE	989,068	989,068
Cormorant Asset Management LP	[2025-06-30]	DFND	800,189	800,189
Vanguard Group Inc	[2025-06-30]	SOLE	0	453,373
SilverArc Capital Management LLC	[2025-06-30]	SOLE	286,807	286,807
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	279,258	279,258
BlackRock, Inc.	[2025-06-30]	SOLE	201,006	205,795
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	175,000	175,000
Geode Capital Management LLC	[2025-06-30]	DFND	136,927	136,927
Cantor Fitzgerald L P	[2025-06-30]	DFND	0	76,682
UBS Group AG	[2025-06-30]	DFND	51,924	51,924
Barclays PLC	[2025-06-30]	SOLE	50,558	50,558
Northern Trust Corp	[2025-06-30]	DFND	44,228	44,228
State Street Corp	[2025-06-30]	DFND	36,897	37,312
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	35,494
Goldman Sachs Group Inc	[2025-06-30]	DFND	18,595	18,595
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	14,240	14,240
Morgan Stanley	[2025-06-30]	DFND	7,229	8,960
Bank of America Corp /DE/	[2025-06-30]	DFND	971	7,989
Vanguard Group Inc	[2025-06-30]	DFND	0	7,604
New York State Common Retirement Fund	[2025-06-30]	SOLE	7,300	7,300
Deutsche Bank AG	[2025-06-30]	DFND	0	5,725
RhumbLine Advisers	[2025-06-30]	SOLE	2,344	5,489
Wells Fargo & Company/MN	[2025-06-30]	DFND	3,239	3,239
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	[2025-06-30]	DFND	3,091	3,091
JPMorgan Chase & Co	[2025-06-30]	DFND	0	2,677
Citigroup Inc	[2025-06-30]	DFND	1,962	1,962
Tower Research Capital LLC (TRC)	[2025-06-30]	DFND	1,268	1,268
STRS Ohio	[2025-06-30]	SOLE	1,100	1,100
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