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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock, Inc.	[2025-06-30]	SOLE	17,923,424	18,373,961
Vanguard Group Inc	[2025-06-30]	SOLE	0	14,354,498
State Street Corp	[2025-06-30]	DFND	7,655,291	7,997,153
Geode Capital Management LLC	[2025-06-30]	DFND	6,074,458	6,074,458
Morgan Stanley	[2025-06-30]	DFND	4,361,067	5,339,654
Renaissance Technologies LLC	[2025-06-30]	SOLE	4,194,427	4,194,427
Goldman Sachs Group Inc	[2025-06-30]	DFND	3,933,432	3,934,002
MPM BioImpact LLC	[2025-06-30]	SOLE	2,889,125	2,889,125
Nuveen, LLC	[2025-06-30]	DFND	2,700,981	2,708,676
Franklin Resources Inc	[2025-06-30]	DFND	2,665,386	2,667,412
Citadel Advisors LLC	[2025-06-30]	DFND	2,541,590	2,541,590
Millennium Management LLC	[2025-06-30]	SOLE	2,163,499	2,163,499
Northern Trust Corp	[2025-06-30]	DFND	2,095,638	2,095,638
Nantahala Capital Management LLC	[2025-06-30]	SOLE	2,000,000	2,000,000
Great Point Partners LLC	[2025-06-30]	SOLE	0	1,985,915
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	1,950,000	1,950,000
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	1,714,544	1,714,544
JPMorgan Chase & Co	[2025-06-30]	DFND	1,417,321	1,652,746
Informed Momentum Co LLC	[2025-06-30]	SOLE	564,058	1,454,328
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	1,112,205	1,205,128
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	1,180,759	1,180,759
Bank of America Corp /DE/	[2025-06-30]	DFND	103,237	1,110,480
Woodline Partners LP	[2025-06-30]	SOLE	1,001,360	1,001,360
Susquehanna International Group LLP	[2025-06-30]	OTR	791,352	930,352
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	685,341	861,816
FMR LLC	[2025-06-30]	DFND	805,846	813,982
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	749,015	749,015
Wellington Management Group LLP	[2025-06-30]	DFND	0	695,728
UBS Group AG	[2025-06-30]	DFND	596,962	639,462
Federated Hermes Inc	[2025-06-30]	DFND	617,318	617,318
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