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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock, Inc.	[2025-06-30]	SOLE	27,000,144	27,854,404
Vanguard Group Inc	[2025-06-30]	SOLE	0	18,104,017
State Street Corp	[2025-06-30]	DFND	7,634,061	8,208,256
Baker Bros Advisors LP	[2025-06-30]	SOLE	6,410,603	6,410,603
Renaissance Technologies LLC	[2025-06-30]	SOLE	5,810,160	5,810,160
JPMorgan Chase & Co	[2025-06-30]	DFND	4,329,687	4,836,294
RTW Investments LP	[2025-06-30]	SOLE	4,682,289	4,682,289
Geode Capital Management LLC	[2025-06-30]	DFND	4,023,552	4,023,552
American Century Companies Inc	[2025-06-30]	DFND	3,475,558	3,657,223
PRIMECAP Management Co/CA/	[2025-06-30]	SOLE	2,816,950	2,902,510
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	2,900,000	2,900,000
Holocene Advisors LP	[2025-06-30]	SOLE	2,853,768	2,853,768
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	2,519,772	2,729,817
Commodore Capital LP	[2025-06-30]	SOLE	2,450,000	2,450,000
Bank of America Corp /DE/	[2025-06-30]	DFND	115,353	2,155,087
Loomis Sayles & Co L P	[2025-06-30]	DFND	2,020,619	2,109,894
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	2,091,927	2,092,049
Nuveen, LLC	[2025-06-30]	DFND	2,015,853	2,048,073
Norges Bank	[2025-06-30]	SOLE	1,863,895	1,863,895
Morgan Stanley	[2025-06-30]	DFND	1,465,339	1,802,052
Northern Trust Corp	[2025-06-30]	DFND	1,708,158	1,727,516
Wellington Management Group LLP	[2025-06-30]	DFND	0	1,700,103
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,619,669	1,664,627
Artisan Partners Limited Partnership	[2025-06-30]	SOLE	1,402,802	1,541,807
Bank of New York Mellon Corp	[2025-06-30]	DFND	1,471,825	1,535,886
First Trust Advisors LP	[2025-06-30]	SOLE	1,397,281	1,397,281
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	1,375,569	1,375,569
UBS Group AG	[2025-06-30]	DFND	1,294,231	1,342,402
FMR LLC	[2025-06-30]	DFND	1,259,814	1,278,006
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	1,135,478
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