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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
AyurMaya Capital Management Company, LP	[2025-06-30]	SOLE	15,139,707	15,139,707
Foresite Capital Management V, LLC	[2025-06-30]	SOLE	5,779,348	5,779,348
Samsara Biocapital LLC	[2025-06-30]	SOLE	4,801,370	4,801,370
venBio Partners LLC	[2025-06-30]	SOLE	4,619,803	4,619,803
Foresite Capital Management VI LLC	[2025-06-30]	SOLE	4,247,670	4,247,670
BlackRock, Inc.	[2025-06-30]	SOLE	4,082,580	4,175,713
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,365,320
Nextech Invest Ltd	[2025-06-30]	SOLE	2,915,998	2,915,998
Trium Capital LLP	[2025-06-30]	SOLE	2,648,039	2,648,039
Cormorant Asset Management LP	[2025-06-30]	DFND	2,147,396	2,147,396
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,996,797
SR One Capital Management LP	[2025-06-30]	SOLE	1,959,896	1,959,896
OrbiMed Advisors LLC	[2025-06-30]	SOLE	1,926,423	1,926,423
Madison Avenue Partners LP	[2025-06-30]	SOLE	1,842,269	1,842,269
Susquehanna International Group LLP	[2025-06-30]	OTR	609,065	1,635,765
Velan Capital Investment Management LP	[2025-06-30]	SOLE	1,620,846	1,620,846
Baker Bros Advisors LP	[2025-06-30]	SOLE	1,562,500	1,562,500
Jane Street Group LLC	[2025-06-30]	DFND	1,014,144	1,440,844
Tybourne Capital Management HK Ltd	[2025-06-30]	SOLE	1,399,250	1,399,250
General Atlantic LP	[2025-06-30]	SOLE	1,297,530	1,297,530
BML Capital Management LLC	[2025-06-30]	SOLE	0	1,210,415
UBS Group AG	[2025-06-30]	DFND	1,207,166	1,207,555
Geode Capital Management LLC	[2025-06-30]	DFND	1,167,832	1,167,832
State Street Corp	[2025-06-30]	DFND	1,050,603	1,109,091
Yu Fan	[2025-06-30]	SOLE	789,618	789,618
Opaleye Management Inc	[2025-06-30]	SOLE	775,000	775,000
HAP Trading, LLC	[2025-06-30]	SOLE	669,400	669,400
Omega Fund Management LLC	[2025-06-30]	SOLE	653,223	653,223
Cantor Fitzgerald L P	[2025-06-30]	DFND	0	559,201
Millennium Management LLC	[2025-06-30]	SOLE	501,085	501,085
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