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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	12,222,222	12,222,222
EcoR1 Capital LLC	[2025-06-30]	SOLE	11,895,808	11,895,808
Vanguard Group Inc	[2025-06-30]	SOLE	0	10,000,848
Morgan Stanley	[2025-06-30]	DFND	9,720,601	9,752,201
Wellington Management Group LLP	[2025-06-30]	DFND	0	8,976,962
Deep Track Capital LP	[2025-06-30]	SOLE	7,000,000	7,000,000
BlackRock, Inc.	[2025-06-30]	SOLE	6,089,984	6,403,955
AQR Capital Management LLC	[2025-06-30]	DFND	5,534,323	5,838,045
UBS Group AG	[2025-06-30]	DFND	4,716,405	4,735,311
State Street Corp	[2025-06-30]	DFND	3,284,654	3,562,721
Suvretta Capital Management LLC	[2025-06-30]	SOLE	2,878,000	2,878,000
Marshall Wace LLP	[2025-06-30]	OTR	0	2,704,837
Siren, L.L.C.	[2025-06-30]	DFND	2,578,396	2,578,396
Jennison Associates LLC	[2025-06-30]	DFND	2,481,588	2,482,368
Bank of America Corp /DE/	[2025-06-30]	DFND	84,768	2,426,628
Norges Bank	[2025-06-30]	SOLE	2,367,224	2,367,224
Geode Capital Management LLC	[2025-06-30]	DFND	1,995,271	1,995,271
Amundi	[2025-06-30]	DFND	1,604,105	1,604,105
OrbiMed Advisors LLC	[2025-06-30]	DFND	161,600	1,532,300
Deutsche Bank AG	[2025-06-30]	DFND	1,355,176	1,482,158
Polar Capital Holdings Plc	[2025-06-30]	DFND	1,352,175	1,352,175
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	1,295,659
Braidwell LP	[2025-06-30]	SOLE	1,121,034	1,121,034
Wells Fargo & Company/MN	[2025-06-30]	DFND	1,041,473	1,043,655
Susquehanna International Group LLP	[2025-06-30]	OTR	328,726	1,011,426
Logos Global Management LP	[2025-06-30]	SOLE	1,000,000	1,000,000
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	989,143	989,143
Octagon Capital Advisors LP	[2025-06-30]	SOLE	903,500	903,500
Camber Capital Management LP	[2025-06-30]	SOLE	850,000	850,000
Ameriprise Financial Inc	[2025-06-30]	DFND	0	750,161
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