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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	5,306,457	5,423,508
Janus Henderson Group PLC	[2025-06-30]	DFND	0	2,565,399
Artisan Partners Limited Partnership	[2025-06-30]	SOLE	2,010,189	2,349,776
Capital World Investors	[2025-06-30]	DFND	1,943,676	1,951,082
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	1,175,000	1,175,000
Citadel Advisors LLC	[2025-06-30]	DFND	901,570	901,570
Clearbridge Investments LLC	[2025-06-30]	SOLE	739,638	772,866
RTW Investments LP	[2025-06-30]	SOLE	673,497	673,497
Bellevue Group AG	[2025-06-30]	DFND	571,039	571,039
BlackRock, Inc.	[2025-06-30]	SOLE	529,787	550,146
Millennium Management LLC	[2025-06-30]	SOLE	429,844	429,844
Morgan Stanley	[2025-06-30]	DFND	383,300	429,291
Wellington Management Group LLP	[2025-06-30]	DFND	0	405,333
Bank of America Corp /DE/	[2025-06-30]	DFND	2,376	336,120
SEI Investments Co	[2025-06-30]	SOLE	316,399	316,399
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	297,113	297,113
Franklin Resources Inc	[2025-06-30]	DFND	245,886	277,397
Jennison Associates LLC	[2025-06-30]	DFND	263,715	264,647
Jefferies Financial Group Inc.	[2025-06-30]	DFND	246,800	246,800
Invesco Ltd.	[2025-06-30]	DFND	0	243,746
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	210,264	210,264
OrbiMed Advisors LLC	[2025-06-30]	DFND	30,200	208,000
American Century Companies Inc	[2025-06-30]	DFND	154,077	205,906
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	180,245	197,286
Braidwell LP	[2025-06-30]	SOLE	194,491	194,491
BAMCO Inc /NY/	[2025-06-30]	DFND	0	180,733
Marshall Wace LLP	[2025-06-30]	OTR	0	177,724
Allspring Global Investments Holdings, LLC	[2025-06-30]	DFND	19,406	176,454
Rock Springs Capital Management LP	[2025-06-30]	SOLE	175,750	175,750
1832 Asset Management L.P.	[2025-06-30]	SOLE	172,400	172,400
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