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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	9,853,302	9,853,302
5AM Venture Management LLC	[2025-06-30]	SOLE	2,353,304	2,353,304
VR Adviser LLC	[2025-06-30]	SOLE	1,609,569	1,609,569
venBio Partners LLC	[2025-06-30]	SOLE	1,148,975	1,148,975
Franklin Resources Inc	[2025-06-30]	DFND	520,327	520,327
BlackRock, Inc.	[2025-06-30]	SOLE	483,016	485,727
Millennium Management LLC	[2025-06-30]	SOLE	327,067	327,067
Samsara Biocapital LLC	[2025-06-30]	SOLE	291,666	291,666
Woodline Partners LP	[2025-06-30]	SOLE	283,124	283,124
Vanguard Group Inc	[2025-06-30]	SOLE	0	227,462
Wellington Management Group LLP	[2025-06-30]	DFND	0	194,108
Geode Capital Management LLC	[2025-06-30]	DFND	159,041	159,041
Citadel Advisors LLC	[2025-06-30]	DFND	153,739	153,739
Goldman Sachs Group Inc	[2025-06-30]	DFND	118,003	118,003
Alyeska Investment Group LP	[2025-06-30]	SOLE	100,000	100,000
HRT Financial LP	[2025-06-30]	DFND	77,656	77,656
State Street Corp	[2025-06-30]	DFND	62,874	62,874
Marshall Wace LLP	[2025-06-30]	OTR	0	52,213
Morgan Stanley	[2025-06-30]	DFND	46,247	46,247
Acuta Capital Partners LLC	[2025-06-30]	SOLE	45,456	45,456
Jane Street Group LLC	[2025-06-30]	DFND	44,215	44,215
FMR LLC	[2025-06-30]	DFND	40,039	42,277
Squarepoint Ops LLC	[2025-06-30]	DFND	0	41,395
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	38,692	38,692
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	35,000	35,000
Northern Trust Corp	[2025-06-30]	DFND	34,964	34,964
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	31,567	31,567
Ground Swell Capital LLC	[2025-06-30]	SOLE	24,849	24,849
Two Sigma Investments LP	[2025-06-30]	SOLE	21,371	21,371
Jain Global LLC	[2025-06-30]	SOLE	17,171	17,171
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