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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock, Inc.	[2025-06-30]	SOLE	19,120,040	19,424,472
Vanguard Group Inc	[2025-06-30]	SOLE	0	15,243,118
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	10,600,000	10,600,000
State Street Corp	[2025-06-30]	DFND	6,004,663	6,371,056
Slate Path Capital LP	[2025-06-30]	SOLE	5,232,000	5,232,000
FMR LLC	[2025-06-30]	DFND	5,141,099	5,170,310
Geode Capital Management LLC	[2025-06-30]	DFND	2,978,505	2,978,505
Siren, L.L.C.	[2025-06-30]	DFND	2,669,880	2,669,880
Goldman Sachs Group Inc	[2025-06-30]	DFND	2,188,181	2,196,614
Marshall Wace LLP	[2025-06-30]	OTR	0	2,155,998
Norges Bank	[2025-06-30]	SOLE	1,924,957	1,924,957
Morgan Stanley	[2025-06-30]	DFND	1,620,485	1,705,266
UBS Group AG	[2025-06-30]	DFND	1,185,766	1,600,596
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	SOLE	1,205,761	1,304,797
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	OTR	12,414	1,249,156
Northern Trust Corp	[2025-06-30]	DFND	1,202,333	1,206,221
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	1,170,644	1,170,745
Aberdeen Group plc	[2025-06-30]	DFND	960,245	960,245
Baker Bros Advisors LP	[2025-06-30]	SOLE	939,174	939,174
Western Financial Corp/CA	[2025-06-30]	SOLE	820,239	820,239
Bank of New York Mellon Corp	[2025-06-30]	DFND	774,573	818,079
Invesco Ltd.	[2025-06-30]	DFND	0	762,665
Woodline Partners LP	[2025-06-30]	SOLE	746,156	746,156
Bank of America Corp /DE/	[2025-06-30]	DFND	121,488	625,996
Principal Financial Group Inc	[2025-06-30]	DFND	623,097	623,097
Privium Fund Management B.V.	[2025-06-30]	SOLE	612,214	612,214
Trexquant Investment LP	[2025-06-30]	SOLE	503,654	503,654
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	482,055	482,055
Fisher Asset Management LLC	[2025-06-30]	DFND	327,528	451,655
Public Sector Pension Investment Board	[2025-06-30]	SOLE	428,386	428,386
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