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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Tang Capital Management LLC	[2025-06-30]	OTR	0	10,029,500
BlackRock, Inc.	[2025-06-30]	SOLE	7,465,138	7,693,156
NEA Management Company LLC	[2025-06-30]	DFND	3,969,834	3,969,834
State Street Corp	[2025-06-30]	DFND	2,315,934	2,795,090
Morgan Stanley	[2025-06-30]	DFND	1,903,688	2,396,239
Armistice Capital LLC	[2025-06-30]	SOLE	1,629,600	1,629,600
Geode Capital Management LLC	[2025-06-30]	DFND	1,577,060	1,577,060
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,501,916
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	1,242,512	1,242,512
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,157,800	1,157,800
Arrowstreet Capital Limited Partnership	[2025-06-30]	DFND	1,076,118	1,076,118
Northern Trust Corp	[2025-06-30]	DFND	901,055	902,158
Jane Street Group LLC	[2025-06-30]	DFND	589,527	894,727
Jupiter Asset Management Ltd	[2025-06-30]	SOLE	889,727	892,329
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	633,883	748,113
Susquehanna International Group LLP	[2025-06-30]	OTR	181,783	732,383
Readystate Asset Management LP	[2025-06-30]	SOLE	657,835	657,835
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	650,191	650,191
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt	[2025-06-30]	DFND	0	565,956
Rice Hall James & Associates LLC	[2025-06-30]	SOLE	330,267	550,501
Schroder Investment Management Group	[2025-06-30]	SOLE	547,802	547,802
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	511,731	511,731
Woodline Partners LP	[2025-06-30]	SOLE	500,416	500,416
Squarepoint Ops LLC	[2025-06-30]	DFND	0	483,937
Bank of America Corp /DE/	[2025-06-30]	DFND	29,058	470,791
Caption Management LLC	[2025-06-30]	SOLE	449,044	449,044
Goldman Sachs Group Inc	[2025-06-30]	DFND	438,110	439,020
JPMorgan Chase & Co	[2025-06-30]	DFND	308,508	438,349
Trexquant Investment LP	[2025-06-30]	SOLE	399,433	399,433
Jump Financial, LLC	[2025-06-30]	DFND	390,101	390,101
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