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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
HHLR Advisors Ltd	[2025-06-30]	OTR	0	4,484,672
Infinitum Asset Management LLC	[2025-06-30]	SOLE	3,418,923	3,418,923
Suvretta Capital Management LLC	[2025-06-30]	SOLE	3,412,788	3,412,788
OrbiMed Advisors LLC	[2025-06-30]	SOLE	3,027,328	3,027,328
FMR LLC	[2025-06-30]	DFND	2,057,656	2,058,069
Octagon Capital Advisors LP	[2025-06-30]	SOLE	1,946,054	1,946,054
Novo Holdings A/S	[2025-06-30]	SOLE	1,872,142	1,872,142
BlackRock, Inc.	[2025-06-30]	SOLE	1,794,296	1,838,376
Sofinnova Investments Inc	[2025-06-30]	SOLE	1,696,752	1,696,752
General Catalyst Group Management LLC	[2025-06-30]	DFND	1,494,786	1,494,786
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,440,287
State Street Corp	[2025-06-30]	DFND	704,066	740,792
Siren, L.L.C.	[2025-06-30]	DFND	700,000	700,000
HSG Holding Ltd	[2025-06-30]	DFND	663,308	663,308
Hidden Lake Asset Management LP	[2025-06-30]	SOLE	606,851	606,851
Geode Capital Management LLC	[2025-06-30]	DFND	596,018	596,018
Fund 1 Investments, LLC	[2025-06-30]	DFND	528,395	528,395
Cooperman Leon G	[2025-06-30]	SOLE	421,278	421,278
Goldman Sachs Group Inc	[2025-06-30]	DFND	339,191	339,196
Squarepoint Ops LLC	[2025-06-30]	DFND	0	204,355
Northern Trust Corp	[2025-06-30]	DFND	203,187	203,187
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	188,202	188,202
Millennium Management LLC	[2025-06-30]	SOLE	176,169	176,169
Woodline Partners LP	[2025-06-30]	SOLE	146,916	146,916
Morgan Stanley	[2025-06-30]	DFND	100,866	101,354
UBS Group AG	[2025-06-30]	DFND	86,588	86,588
Moody Aldrich Partners LLC	[2025-06-30]	SOLE	31,855	71,575
Wellington Management Group LLP	[2025-06-30]	DFND	0	66,329
Bank of New York Mellon Corp	[2025-06-30]	DFND	50,231	58,778
Verition Fund Management LLC	[2025-06-30]	SOLE	56,502	56,502
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