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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
L1 Capital Pty Ltd	[2025-06-30]	SOLE	2,812,000	2,812,000
SIO Capital Management LLC	[2025-06-30]	SOLE	1,839,022	1,839,022
Perceptive Advisors LLC	[2025-06-30]	SOLE	1,705,130	1,705,130
Nantahala Capital Management LLC	[2025-06-30]	SOLE	1,693,666	1,693,666
Ensign Peak Advisors, Inc	[2025-06-30]	SOLE	1,441,132	1,441,132
Rhenman & Partners Asset Management AB	[2025-06-30]	SOLE	1,250,763	1,250,763
JPMorgan Chase & Co	[2025-06-30]	DFND	1,058,158	1,068,328
BlackRock, Inc.	[2025-06-30]	SOLE	1,013,492	1,027,952
Alyeska Investment Group LP	[2025-06-30]	SOLE	550,000	550,000
Adar1 Capital Management LLC	[2025-06-30]	SOLE	531,515	531,515
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	425,000	425,000
Geode Capital Management LLC	[2025-06-30]	DFND	420,427	420,427
Vanguard Group Inc	[2025-06-30]	SOLE	0	381,886
UBS Group AG	[2025-06-30]	DFND	301,158	301,158
State Street Corp	[2025-06-30]	DFND	170,748	188,715
Marex Group plc	[2025-06-30]	DFND	169,029	169,029
Symmetry Investments LP	[2025-06-30]	DFND	139,398	139,398
Barclays PLC	[2025-06-30]	SOLE	134,304	134,304
Northern Trust Corp	[2025-06-30]	DFND	132,900	132,900
Oasis Management Co Ltd.	[2025-06-30]	SOLE	112,207	112,207
Millennium Management LLC	[2025-06-30]	SOLE	78,996	78,996
Goldman Sachs Group Inc	[2025-06-30]	DFND	76,656	76,656
Morgan Stanley	[2025-06-30]	DFND	57,789	71,427
Bearing Point Capital LLC	[2025-06-30]	SOLE	0	70,500
Nuveen, LLC	[2025-06-30]	DFND	64,620	64,620
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	53,872	53,872
Susquehanna International Group LLP	[2025-06-30]	OTR	43,618	43,618
Bank of New York Mellon Corp	[2025-06-30]	DFND	34,847	35,289
Invesco Ltd.	[2025-06-30]	DFND	0	34,849
FMR LLC	[2025-06-30]	DFND	26,431	33,268
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