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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	3,117,047	3,125,103
Nextech Invest Ltd	[2025-06-30]	SOLE	1,228,069	1,228,069
Citadel Advisors LLC	[2025-06-30]	DFND	830,936	830,936
Sectoral Asset Management Inc	[2025-06-30]	SOLE	678,574	678,574
Redmile Group LLC	[2025-06-30]	SOLE	589,034	589,034
Wellington Management Group LLP	[2025-06-30]	DFND	0	556,233
Vanguard Group Inc	[2025-06-30]	SOLE	0	480,838
Alyeska Investment Group LP	[2025-06-30]	SOLE	300,000	300,000
Almitas Capital LLC	[2025-06-30]	SOLE	235,505	235,505
Millennium Management LLC	[2025-06-30]	SOLE	213,561	213,561
Northern Trust Corp	[2025-06-30]	DFND	207,500	207,500
RBF Capital, LLC	[2025-06-30]	SOLE	200,000	200,000
Ensign Peak Advisors, Inc	[2025-06-30]	SOLE	187,500	187,500
SIO Capital Management LLC	[2025-06-30]	SOLE	163,679	163,679
Renaissance Technologies LLC	[2025-06-30]	SOLE	121,000	121,000
Stonepine Capital Management LLC	[2025-06-30]	SOLE	106,175	106,175
Goldman Sachs Group Inc	[2025-06-30]	DFND	70,304	70,304
BlackRock, Inc.	[2025-06-30]	SOLE	64,258	64,258
Geode Capital Management LLC	[2025-06-30]	DFND	58,903	58,903
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	55,242	55,242
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	50,500	50,500
XTX Topco Ltd	[2025-06-30]	DFND	40,064	40,064
Walleye Capital LLC	[2025-06-30]	SOLE	39,624	39,624
Susquehanna International Group LLP	[2025-06-30]	OTR	32,211	32,211
HRT Financial LP	[2025-06-30]	DFND	27,509	27,509
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	21,542	21,542
Squarepoint Ops LLC	[2025-06-30]	DFND	0	18,399
Morgan Stanley	[2025-06-30]	DFND	2,239	16,739
State Street Corp	[2025-06-30]	DFND	15,962	15,962
Abel Hall LLC	[2025-06-30]	SOLE	0	14,399
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