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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Enavate Sciences GP, LLC	[2025-06-30]	SOLE	3,785,802	3,785,802
5AM Venture Management LLC	[2025-06-30]	SOLE	2,927,915	2,927,915
Ah Capital Management LLC	[2025-06-30]	SOLE	2,125,339	2,125,339
HarbourVest Partners LLC	[2025-06-30]	SOLE	1,271,948	1,271,948
FMR LLC	[2025-06-30]	DFND	605,492	607,946
Vanguard Group Inc	[2025-06-30]	SOLE	0	328,539
Alyeska Investment Group LP	[2025-06-30]	SOLE	200,000	200,000
Millennium Management LLC	[2025-06-30]	SOLE	133,036	133,036
BlackRock, Inc.	[2025-06-30]	SOLE	83,602	84,221
Victory Capital Management Inc	[2025-06-30]	SOLE	83,060	83,060
Geode Capital Management LLC	[2025-06-30]	DFND	75,199	75,199
Goldman Sachs Group Inc	[2025-06-30]	DFND	26,511	26,511
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	25,000	25,000
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	14,871	14,871
Verition Fund Management LLC	[2025-06-30]	SOLE	14,760	14,760
Northern Trust Corp	[2025-06-30]	DFND	14,615	14,615
Cantor Fitzgerald L P	[2025-06-30]	DFND	0	12,320
UBS Group AG	[2025-06-30]	DFND	5,088	5,088
Tower Research Capital LLC (TRC)	[2025-06-30]	DFND	3,830	3,830
Morgan Stanley	[2025-06-30]	DFND	1,687	1,687
Royal Bank of Canada	[2025-06-30]	DFND	953	953
Bank of America Corp /DE/	[2025-06-30]	DFND	0	652
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	427
Vanguard Group Inc	[2025-06-30]	DFND	0	352
JPMorgan Chase & Co	[2025-06-30]	DFND	238	238
Wells Fargo & Company/MN	[2025-06-30]	DFND	119	119
NISA Investment Advisors LLC	[2025-06-30]	SOLE	101	101
CWM LLC	[2025-06-30]	SOLE	3	68
SBI Securities Co., Ltd.	[2025-06-30]	DFND	20	20
Eversource Wealth Advisors LLC	[2025-06-30]	SOLE	3	3
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