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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
VR Adviser LLC	[2025-06-30]	SOLE	987,259	987,259
Foresite Capital Management VI LLC	[2025-06-30]	SOLE	787,121	787,121
Woodline Partners LP	[2025-06-30]	SOLE	165,640	165,640
Wellington Shields Capital Management LLC	[2025-06-30]	SOLE	0	90,845
Adar1 Capital Management LLC	[2025-06-30]	SOLE	44,120	44,120
Renaissance Technologies LLC	[2025-06-30]	SOLE	39,200	39,200
Citadel Advisors LLC	[2025-06-30]	DFND	36,246	36,246
Wellington Shields & Co LLC	[2025-06-30]	SOLE	0	30,091
Geode Capital Management LLC	[2025-06-30]	DFND	18,808	18,808
Bank of America Corp /DE/	[2025-06-30]	DFND	0	12,061
Two Sigma Securities LLC	[2025-06-30]	SOLE	11,599	11,599
Susquehanna International Group LLP	[2025-06-30]	OTR	10,151	10,151
Royal Bank of Canada	[2025-06-30]	DFND	9,950	9,950
UBS Group AG	[2025-06-30]	DFND	954	954
Wells Fargo & Company/MN	[2025-06-30]	DFND	0	505
Morgan Stanley	[2025-06-30]	DFND	250	365
BlackRock, Inc.	[2025-06-30]	SOLE	296	296
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	134
Simplex Trading LLC	[2025-06-30]	SOLE	26	26
JPMorgan Chase & Co	[2025-06-30]	DFND	25	25
Citigroup Inc	[2025-06-30]	DFND	19	19
Northwestern Mutual Wealth Management Co	[2025-06-30]	DFND	0	13
Colonial Trust Co / SC	[2025-06-30]	SOLE	11	11
MAI Capital Management	[2025-06-30]	SOLE	0	5
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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