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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Artal Group S.A.	[2025-06-30]	DFND	9,507,990	9,507,990
Vanguard Group Inc	[2025-06-30]	SOLE	0	8,870,260
BlackRock, Inc.	[2025-06-30]	SOLE	7,980,867	8,321,788
Jennison Associates LLC	[2025-06-30]	DFND	5,249,889	6,143,870
Capital Research Global Investors	[2025-06-30]	DFND	5,165,108	5,165,108
FMR LLC	[2025-06-30]	DFND	4,322,009	4,332,774
Susquehanna International Group LLP	[2025-06-30]	OTR	413,364	4,044,564
Citadel Advisors LLC	[2025-06-30]	DFND	3,311,183	3,311,183
State Street Corp	[2025-06-30]	DFND	2,309,078	2,543,335
Bank of America Corp /DE/	[2025-06-30]	DFND	56,029	2,366,417
Jane Street Group LLC	[2025-06-30]	DFND	1,146,992	2,308,992
UBS Group AG	[2025-06-30]	DFND	1,959,408	2,140,639
Capital International Investors	[2025-06-30]	DFND	2,059,183	2,059,183
Morgan Stanley	[2025-06-30]	DFND	961,855	2,012,874
Squarepoint Ops LLC	[2025-06-30]	DFND	0	1,879,277
Geode Capital Management LLC	[2025-06-30]	DFND	1,607,996	1,622,898
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,476,160	1,572,928
AllianceBernstein LP	[2025-06-30]	DFND	1,249,004	1,353,058
Champlain Investment Partners LLC	[2025-06-30]	SOLE	1,246,635	1,351,955
Point72 Asset Management LP	[2025-06-30]	DFND	0	1,267,127
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,085,956	1,085,956
Franklin Resources Inc	[2025-06-30]	DFND	1,069,884	1,082,183
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	1,053,914	1,053,914
Clearbridge Investments LLC	[2025-06-30]	SOLE	904,032	905,154
Wells Fargo & Company/MN	[2025-06-30]	DFND	551,191	872,853
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	764,280	764,280
JPMorgan Chase & Co	[2025-06-30]	DFND	371,788	763,836
Bank of New York Mellon Corp	[2025-06-30]	DFND	688,406	763,235
Congress Asset Management Co	[2025-06-30]	SOLE	636,455	751,994
Wolverine Trading LLC	[2025-06-30]	DFND	0	728,871
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