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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	1,414,190	1,414,190
Fairmount Funds Management LLC	[2025-06-30]	SOLE	1,387,866	1,387,866
VR Adviser LLC	[2025-06-30]	SOLE	1,387,864	1,387,864
BVF Inc/IL	[2025-06-30]	DFND	0	1,387,863
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	642,721	642,721
Logos Global Management LP	[2025-06-30]	SOLE	553,686	553,686
Boxer Capital Management LLC	[2025-06-30]	SOLE	0	453,686
Deep Track Capital LP	[2025-06-30]	SOLE	453,686	453,686
Perceptive Advisors LLC	[2025-06-30]	SOLE	453,686	453,686
Commodore Capital LP	[2025-06-30]	SOLE	453,686	453,686
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	453,685	453,685
Soleus Capital Management LP	[2025-06-30]	SOLE	400,000	400,000
Driehaus Capital Management LLC	[2025-06-30]	SOLE	302,457	302,457
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	280,031	280,031
Braidwell LP	[2025-06-30]	SOLE	261,504	261,504
Wellington Management Group LLP	[2025-06-30]	DFND	0	179,886
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	100,912	100,912
Blackstone Inc.	[2025-06-30]	OTR	0	75,614
Tang Capital Management LLC	[2025-06-30]	OTR	0	50,152
Jefferies Financial Group Inc.	[2025-06-30]	DFND	27,096	27,096
Morgan Stanley	[2025-06-30]	DFND	15,387	15,394
Bank of America Corp /DE/	[2025-06-30]	DFND	0	9,231
BlackRock, Inc.	[2025-06-30]	SOLE	5,973	6,051
Barclays PLC	[2025-06-30]	SOLE	286	286
UBS Group AG	[2025-06-30]	DFND	223	223
Group One Trading LLC	[2025-06-30]	SOLE	162	162
SBI Securities Co., Ltd.	[2025-06-30]	DFND	68	68
Raymond James Financial Inc	[2025-06-30]	DFND	0	50
Royal Bank of Canada	[2025-06-30]	DFND	20	20
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	4
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