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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Decheng Capital LLC	[2025-06-30]	SOLE	6,371,669	6,371,669
Vanguard Group Inc	[2025-06-30]	SOLE	0	5,796,710
BlackRock, Inc.	[2025-06-30]	SOLE	4,368,180	4,456,423
FMR LLC	[2025-06-30]	DFND	3,854,166	3,856,261
TCG Crossover Management LLC	[2025-06-30]	SOLE	3,670,206	3,670,206
Braidwell LP	[2025-06-30]	SOLE	3,283,317	3,283,317
Kynam Capital Management LP	[2025-06-30]	SOLE	2,457,667	2,457,667
UBS Group AG	[2025-06-30]	DFND	2,229,245	2,229,245
Foresite Capital Management VI LLC	[2025-06-30]	SOLE	2,221,474	2,221,474
State Street Corp	[2025-06-30]	DFND	2,061,163	2,165,753
AllianceBernstein LP	[2025-06-30]	DFND	1,977,334	2,164,214
OrbiMed Advisors LLC	[2025-06-30]	DFND	362,400	2,027,850
Wellington Management Group LLP	[2025-06-30]	DFND	0	1,898,894
Morgan Stanley	[2025-06-30]	DFND	1,845,982	1,868,148
Bank of America Corp /DE/	[2025-06-30]	DFND	8,745	1,736,769
RTW Investments LP	[2025-06-30]	SOLE	1,701,216	1,701,216
Avidity Partners Management LP	[2025-06-30]	SOLE	1,499,942	1,499,942
Franklin Resources Inc	[2025-06-30]	DFND	1,486,839	1,486,839
Point72 Asset Management LP	[2025-06-30]	DFND	0	1,475,293
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	1,221,757	1,354,383
Geode Capital Management LLC	[2025-06-30]	DFND	1,335,437	1,335,437
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,150,087	1,162,698
Acorn Capital Advisors LLC	[2025-06-30]	SOLE	1,131,501	1,131,501
Polar Capital Holdings Plc	[2025-06-30]	DFND	1,098,662	1,098,662
Foresite Capital Management V, LLC	[2025-06-30]	SOLE	1,004,050	1,004,050
Millennium Management LLC	[2025-06-30]	SOLE	959,968	959,968
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	770,000	770,000
Candriam S.C.A.	[2025-06-30]	SOLE	763,580	763,580
Woodline Partners LP	[2025-06-30]	SOLE	629,357	629,357
Cormorant Asset Management LP	[2025-06-30]	DFND	625,000	625,000
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