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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Medicxi Ventures Management (Jersey) Ltd	[2025-06-30]	SOLE	19,963,157	19,963,157
Index Venture Life Associates VI Ltd	[2025-06-30]	SOLE	9,961,789	9,961,789
General Atlantic LP	[2025-06-30]	SOLE	9,681,818	9,681,818
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	8,403,000	8,403,000
Janus Henderson Group PLC	[2025-06-30]	DFND	0	6,532,768
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	5,000,000	5,000,000
Farallon Capital Management LLC	[2025-06-30]	OTR	4,529,318	4,529,318
First Light Asset Management LLC	[2025-06-30]	SOLE	4,293,411	4,293,411
FMR LLC	[2025-06-30]	DFND	3,826,194	3,826,194
Siren, L.L.C.	[2025-06-30]	DFND	3,460,029	3,460,029
Commodore Capital LP	[2025-06-30]	SOLE	3,298,289	3,298,289
TCG Crossover Management LLC	[2025-06-30]	SOLE	2,890,816	2,890,816
Point72 Asset Management LP	[2025-06-30]	DFND	0	2,591,596
Franklin Resources Inc	[2025-06-30]	DFND	2,543,539	2,543,539
Cormorant Asset Management LP	[2025-06-30]	DFND	2,086,600	2,086,600
Morgan Stanley	[2025-06-30]	DFND	1,776,385	1,793,471
Millennium Management LLC	[2025-06-30]	SOLE	1,657,887	1,721,087
RTW Investments LP	[2025-06-30]	SOLE	1,529,836	1,529,836
Stempoint Capital LP	[2025-06-30]	SOLE	1,106,025	1,265,672
Foresite Capital Management VI LLC	[2025-06-30]	SOLE	1,253,379	1,253,379
Balyasny Asset Management LP	[2025-06-30]	SOLE	1,221,610	1,221,610
Perceptive Advisors LLC	[2025-06-30]	SOLE	1,146,935	1,146,935
American Century Companies Inc	[2025-06-30]	DFND	945,444	1,130,708
Octagon Capital Advisors LP	[2025-06-30]	SOLE	1,030,000	1,030,000
Polar Capital Holdings Plc	[2025-06-30]	DFND	1,000,000	1,000,000
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	900,162	900,162
5AM Venture Management LLC	[2025-06-30]	SOLE	830,945	830,945
Saturn V Capital Management LP	[2025-06-30]	SOLE	793,327	793,327
Tanager Wealth Management LLP	[2025-06-30]	SOLE	0	598,044
Goldman Sachs Group Inc	[2025-06-30]	DFND	596,283	596,283
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