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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Cormorant Asset Management LP	[2025-06-30]	DFND	2,375,000	2,375,000
OrbiMed Advisors LLC	[2025-06-30]	DFND	454,087	1,172,287
Octagon Capital Advisors LP	[2025-06-30]	SOLE	1,115,000	1,115,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	594,800
ProSight Management LP	[2025-06-30]	SOLE	579,893	579,893
BlackRock, Inc.	[2025-06-30]	SOLE	349,203	352,409
Exome Asset Management LLC	[2025-06-30]	SOLE	277,317	277,317
Comerica Bank	[2025-06-30]	SOLE	200,001	200,001
Armistice Capital LLC	[2025-06-30]	SOLE	192,000	192,000
Atle Fund Management AB	[2025-06-30]	SOLE	1,211,516	175,582
Millennium Management LLC	[2025-06-30]	SOLE	159,162	159,162
Morgan Stanley	[2025-06-30]	DFND	157,608	158,999
Renaissance Technologies LLC	[2025-06-30]	SOLE	153,539	153,539
Acadian Asset Management LLC	[2025-06-30]	DFND	152,271	152,271
Geode Capital Management LLC	[2025-06-30]	DFND	134,091	134,091
Tang Capital Management LLC	[2025-06-30]	OTR	0	127,520
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	[2025-06-30]	DFND	119,056	119,056
UBS Group AG	[2025-06-30]	DFND	84,538	91,843
Prelude Capital Management LLC	[2025-06-30]	OTR	0	80,347
	[2025-06-30]	SOLE	75,292	75,292
Aberdeen Group plc	[2025-06-30]	DFND	72,226	72,226
Bank of America Corp /DE/	[2025-06-30]	DFND	0	71,893
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	68,148	68,148
Velan Capital Investment Management LP	[2025-06-30]	SOLE	59,000	59,000
State Street Corp	[2025-06-30]	DFND	55,092	55,092
Two Sigma Investments LP	[2025-06-30]	SOLE	45,501	45,501
Goldman Sachs Group Inc	[2025-06-30]	DFND	43,674	43,674
Susquehanna International Group LLP	[2025-06-30]	OTR	43,332	43,332
Citadel Advisors LLC	[2025-06-30]	DFND	38,000	38,000
Northern Trust Corp	[2025-06-30]	DFND	31,651	31,651
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