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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Pfizer Inc	[2025-06-30]	SOLE	4,690,431	4,690,431
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,060,765
Kynam Capital Management LP	[2025-06-30]	SOLE	3,067,774	3,067,774
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	2,272,866	2,272,866
BlackRock, Inc.	[2025-06-30]	SOLE	1,873,359	1,883,476
Millennium Management LLC	[2025-06-30]	SOLE	1,550,589	1,550,589
Two Sigma Advisers LP	[2025-06-30]	SOLE	1,389,400	1,447,800
PFM Health Sciences LP	[2025-06-30]	DFND	0	1,358,831
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,059,809	1,152,771
Geode Capital Management LLC	[2025-06-30]	DFND	980,929	980,929
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	718,540	956,980
Two Sigma Investments LP	[2025-06-30]	SOLE	928,525	928,525
Aberdeen Group plc	[2025-06-30]	DFND	897,579	897,579
Bank of America Corp /DE/	[2025-06-30]	DFND	0	808,900
Goldman Sachs Group Inc	[2025-06-30]	DFND	791,616	791,616
Pale Fire Capital SE	[2025-06-30]	DFND	0	775,055
FMR LLC	[2025-06-30]	DFND	716,521	729,441
Maverick Capital Ltd	[2025-06-30]	SOLE	652,542	652,542
AQR Capital Management LLC	[2025-06-30]	DFND	630,755	630,760
Royal Bank of Canada	[2025-06-30]	DFND	599,117	599,117
Cambridge Investment Research Advisors Inc	[2025-06-30]	SOLE	0	584,446
Renaissance Technologies LLC	[2025-06-30]	SOLE	532,121	532,121
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	529,449	529,449
Jane Street Group LLC	[2025-06-30]	DFND	483,610	483,610
72 Investment Holdings, LLC	[2025-06-30]	DFND	0	474,067
Green Alpha Advisors LLC	[2025-06-30]	SOLE	425,679	425,679
Milestone Asset Management LLC	[2025-06-30]	SOLE	0	409,562
State Street Corp	[2025-06-30]	DFND	358,163	358,163
&Partners	[2025-06-30]	SOLE	336,565	336,565
Morgan Stanley	[2025-06-30]	DFND	311,394	331,481
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