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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BVF Inc/IL	[2025-06-30]	DFND	0	6,293,282
RA Capital Management LP	[2025-06-30]	SOLE	3,566,338	3,566,338
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,269,735
BlackRock, Inc.	[2025-06-30]	SOLE	3,168,109	3,254,152
First Light Asset Management LLC	[2025-06-30]	SOLE	2,600,498	2,600,498
Sphera Funds Management Ltd	[2025-06-30]	DFND	1,959,610	1,990,810
Woodline Partners LP	[2025-06-30]	SOLE	1,671,822	1,671,822
Geode Capital Management LLC	[2025-06-30]	DFND	1,383,940	1,383,940
Blue Owl Capital Holdings LP	[2025-06-30]	DFND	0	1,329,912
Ensign Peak Advisors, Inc	[2025-06-30]	SOLE	1,264,919	1,264,919
Nantahala Capital Management LLC	[2025-06-30]	SOLE	1,141,237	1,141,237
AWM Investment Company Inc	[2025-06-30]	SOLE	1,100,473	1,100,473
Susquehanna International Group LLP	[2025-06-30]	OTR	1,018,919	1,036,219
Ikarian Capital LLC	[2025-06-30]	SOLE	1,000,221	1,000,221
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	998,454	998,454
Zimmer Partners LP	[2025-06-30]	SOLE	980,682	980,682
Alyeska Investment Group LP	[2025-06-30]	SOLE	933,475	933,475
Sanofi	[2025-06-30]	SOLE	814,980	814,980
Siren, L.L.C.	[2025-06-30]	DFND	690,170	690,170
22NW LP	[2025-06-30]	SOLE	636,364	636,364
State Street Corp	[2025-06-30]	DFND	548,807	605,340
Northern Trust Corp	[2025-06-30]	DFND	445,120	445,120
CM Management LLC	[2025-06-30]	SOLE	375,000	375,000
Morgan Stanley	[2025-06-30]	DFND	262,363	345,629
Velan Capital Investment Management LP	[2025-06-30]	SOLE	338,973	338,973
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	293,565
Renaissance Technologies LLC	[2025-06-30]	SOLE	190,673	190,673
Citadel Advisors LLC	[2025-06-30]	DFND	182,760	182,760
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	177,249	177,249
Millennium Management LLC	[2025-06-30]	SOLE	171,669	171,669
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