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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FCPM III Services BV	[2025-06-30]	DFND	0	9,632,561
VR Adviser LLC	[2025-06-30]	SOLE	5,046,414	5,046,414
Kynam Capital Management LP	[2025-06-30]	SOLE	4,994,090	4,994,090
Deep Track Capital LP	[2025-06-30]	SOLE	4,557,575	4,557,575
Blue Owl Capital Holdings LP	[2025-06-30]	DFND	0	3,728,106
Cormorant Asset Management LP	[2025-06-30]	DFND	2,323,595	2,323,595
Bank of America Corp /DE/	[2025-06-30]	DFND	0	2,005,708
Point72 Asset Management LP	[2025-06-30]	DFND	0	1,208,299
Franklin Resources Inc	[2025-06-30]	DFND	1,038,000	1,038,000
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,000,000	1,000,000
Goldman Sachs Group Inc	[2025-06-30]	DFND	899,086	899,086
SR One Capital Management LP	[2025-06-30]	SOLE	747,750	747,750
OrbiMed Advisors LLC	[2025-06-30]	DFND	387,573	677,977
Omega Fund Management LLC	[2025-06-30]	SOLE	526,357	526,357
Sphera Funds Management Ltd	[2025-06-30]	DFND	504,409	504,409
Vestal Point Capital LP	[2025-06-30]	SOLE	370,000	370,000
Morgan Stanley	[2025-06-30]	DFND	350,707	352,768
Marshall Wace LLP	[2025-06-30]	OTR	0	343,928
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	174,570	174,570
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	77,000	77,000
Northern Trust Corp	[2025-06-30]	DFND	33,026	33,026
Geode Capital Management LLC	[2025-06-30]	DFND	29,018	29,018
Adar1 Capital Management LLC	[2025-06-30]	SOLE	27,787	27,787
Citadel Advisors LLC	[2025-06-30]	DFND	23,043	23,043
Pale Fire Capital SE	[2025-06-30]	DFND	0	17,254
Toronto Dominion Bank	[2025-06-30]	DFND	0	14,537
Millennium Management LLC	[2025-06-30]	SOLE	13,030	13,030
Renaissance Technologies LLC	[2025-06-30]	SOLE	11,400	11,400
Paloma Partners Management Co	[2025-06-30]	OTR	0	10,319
Cresset Asset Management LLC	[2025-06-30]	SOLE	0	10,000
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