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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Farallon Capital Management LLC	[2025-06-30]	OTR	2,122,262	2,122,262
Krensavage Asset Management LLC	[2025-06-30]	SOLE	2,114,444	2,114,444
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,953,197
BlackRock, Inc.	[2025-06-30]	SOLE	1,808,125	1,846,905
Millennium Management LLC	[2025-06-30]	SOLE	1,458,593	1,508,593
Marshall Wace LLP	[2025-06-30]	OTR	0	857,412
Stonepine Capital Management LLC	[2025-06-30]	SOLE	604,066	604,066
Janus Henderson Group PLC	[2025-06-30]	DFND	0	523,743
Geode Capital Management LLC	[2025-06-30]	DFND	485,797	485,797
State Street Corp	[2025-06-30]	DFND	438,366	470,270
Renaissance Technologies LLC	[2025-06-30]	SOLE	469,500	469,500
AQR Capital Management LLC	[2025-06-30]	DFND	376,283	384,975
Morgan Stanley	[2025-06-30]	DFND	278,952	286,526
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	273,647	282,276
Trexquant Investment LP	[2025-06-30]	SOLE	264,958	264,958
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	235,991	259,819
Northern Trust Corp	[2025-06-30]	DFND	193,672	193,770
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	157,406	192,070
SIO Capital Management LLC	[2025-06-30]	SOLE	178,774	178,774
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	164,647	164,647
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	SOLE	149,178	149,178
Two Sigma Advisers LP	[2025-06-30]	SOLE	124,800	133,600
JPMorgan Chase & Co	[2025-06-30]	DFND	106,840	130,433
Tang Capital Management LLC	[2025-06-30]	OTR	0	126,655
Goldman Sachs Group Inc	[2025-06-30]	DFND	115,235	116,135
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	106,380	106,380
PDT Partners LLC	[2025-06-30]	SOLE	86,752	86,752
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	83,912	83,912
Two Sigma Investments LP	[2025-06-30]	SOLE	78,455	78,455
SEI Investments Co	[2025-06-30]	SOLE	73,853	73,853
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