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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Gilead Sciences Inc	[2025-06-30]	SOLE	1,875,945	1,875,945
Baker Bros Advisors LP	[2025-06-30]	SOLE	812,814	812,814
Siren, L.L.C.	[2025-06-30]	DFND	566,640	566,640
Knoll Capital Management, LLC	[2025-06-30]	SOLE	498,625	498,625
FMR LLC	[2025-06-30]	DFND	333,290	334,030
Vanguard Group Inc	[2025-06-30]	SOLE	0	298,228
Geode Capital Management LLC	[2025-06-30]	DFND	73,341	73,341
Acadian Asset Management LLC	[2025-06-30]	DFND	55,735	55,735
Susquehanna International Group LLP	[2025-06-30]	OTR	37,265	53,765
Ikarian Capital LLC	[2025-06-30]	SOLE	52,996	52,996
Renaissance Technologies LLC	[2025-06-30]	SOLE	45,570	45,570
Royal Bank of Canada	[2025-06-30]	DFND	28,763	28,852
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	23,948	23,948
Morgan Stanley	[2025-06-30]	DFND	485	19,247
State Street Corp	[2025-06-30]	DFND	16,967	16,967
Northern Trust Corp	[2025-06-30]	DFND	15,661	15,661
BlackRock, Inc.	[2025-06-30]	SOLE	7,003	12,250
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	11,688
Tower Research Capital LLC (TRC)	[2025-06-30]	DFND	3,481	3,481
Vanguard Group Inc	[2025-06-30]	DFND	0	2,591
JPMorgan Chase & Co	[2025-06-30]	DFND	815	815
Bank of America Corp /DE/	[2025-06-30]	DFND	0	481
Simplex Trading LLC	[2025-06-30]	SOLE	341	341
UBS Group AG	[2025-06-30]	DFND	58	63
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	41
Federation des caisses Desjardins du Quebec	[2025-06-30]	DFND	33	33
SBI Securities Co., Ltd.	[2025-06-30]	DFND	13	13
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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