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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Viking Global Investors LP	[2025-06-30]	SOLE	1,787,705	1,787,705
Sanofi	[2025-06-30]	SOLE	1,157,926	1,157,926
Perceptive Advisors LLC	[2025-06-30]	SOLE	977,892	977,892
Hightower Advisors LLC	[2025-06-30]	SOLE	871,759	871,759
BlackRock, Inc.	[2025-06-30]	SOLE	711,547	728,744
Sofinnova Investments Inc	[2025-06-30]	SOLE	708,678	708,678
Woodline Partners LP	[2025-06-30]	SOLE	662,868	662,868
Vanguard Group Inc	[2025-06-30]	SOLE	0	590,264
Millennium Management LLC	[2025-06-30]	SOLE	275,778	275,778
PFM Health Sciences LP	[2025-06-30]	DFND	0	244,261
Geode Capital Management LLC	[2025-06-30]	DFND	225,955	225,955
State Street Corp	[2025-06-30]	DFND	194,459	204,959
Caption Management LLC	[2025-06-30]	SOLE	199,508	199,508
Slotnik Capital LLC	[2025-06-30]	SOLE	0	184,171
Kennedy Capital Management LLC	[2025-06-30]	SOLE	177,318	177,318
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	154,790	154,790
Acadian Asset Management LLC	[2025-06-30]	DFND	120,124	120,124
Northern Trust Corp	[2025-06-30]	DFND	96,274	96,306
Groupe la Francaise	[2025-06-30]	DFND	75,932	75,932
Credit Industriel ET Commercial	[2025-06-30]	DFND	64,217	64,217
Bank of New York Mellon Corp	[2025-06-30]	DFND	45,175	50,478
UBS Group AG	[2025-06-30]	DFND	45,984	45,984
Ikarian Capital LLC	[2025-06-30]	SOLE	42,122	42,122
Laird Norton Wetherby Wealth Management LLC	[2025-06-30]	SOLE	0	40,656
FMR LLC	[2025-06-30]	DFND	38,469	39,071
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	36,206	36,206
Murchinson Ltd	[2025-06-30]	SOLE	33,790	33,790
Birchview Capital LP	[2025-06-30]	SOLE	32,110	32,110
Russell Investments Group, Ltd.	[2025-06-30]	DFND	29,830	29,993
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	28,230
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