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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
SIO Capital Management LLC	[2025-06-30]	SOLE	1,299,300	1,299,300
BlackRock, Inc.	[2025-06-30]	SOLE	1,157,674	1,172,441
Susquehanna International Group LLP	[2025-06-30]	OTR	19,945	1,108,645
Citadel Advisors LLC	[2025-06-30]	DFND	852,700	852,700
Vanguard Group Inc	[2025-06-30]	SOLE	0	826,951
Caption Management LLC	[2025-06-30]	SOLE	734,400	734,400
UBS Group AG	[2025-06-30]	DFND	318,761	449,221
Geode Capital Management LLC	[2025-06-30]	DFND	389,931	389,931
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	354,000	354,000
Dauntless Investment Group, LLC	[2025-06-30]	SOLE	0	341,942
Raymond James Financial Inc	[2025-06-30]	DFND	0	333,477
State Street Corp	[2025-06-30]	DFND	263,039	275,392
Rhenman & Partners Asset Management AB	[2025-06-30]	SOLE	178,284	178,284
Northern Trust Corp	[2025-06-30]	DFND	162,459	162,459
Adar1 Capital Management LLC	[2025-06-30]	SOLE	130,200	130,200
XTX Topco Ltd	[2025-06-30]	DFND	125,847	125,847
Belvedere Trading LLC	[2025-06-30]	SOLE	114,500	114,500
Morgan Stanley	[2025-06-30]	DFND	93,887	102,738
Masters Capital Management LLC	[2025-06-30]	SOLE	100,000	100,000
Millennium Management LLC	[2025-06-30]	SOLE	42,612	92,612
National Bank of Canada /FI/	[2025-06-30]	DFND	0	92,300
JPMorgan Chase & Co	[2025-06-30]	DFND	43,481	73,097
Bank of New York Mellon Corp	[2025-06-30]	DFND	61,108	61,604
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	51,825	51,825
MYDA Advisors LLC	[2025-06-30]	SOLE	50,000	50,000
OrbiMed Advisors LLC	[2025-06-30]	DFND	23,800	50,000
Focus Partners Advisor Solutions LLC	[2025-06-30]	OTR	0	48,813
Royal Bank of Canada	[2025-06-30]	DFND	48,779	48,779
MAI Capital Management	[2025-06-30]	SOLE	17,500	48,238
Scientech Research LLC	[2025-06-30]	SOLE	45,737	45,737
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