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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Darwin Global Management, Ltd.	[2025-06-30]	SOLE	19,344,621	19,344,621
Vanguard Group Inc	[2025-06-30]	SOLE	0	17,323,422
JPMorgan Chase & Co	[2025-06-30]	DFND	14,287,053	15,619,555
BlackRock, Inc.	[2025-06-30]	SOLE	10,633,321	11,142,432
Baker Bros Advisors LP	[2025-06-30]	SOLE	7,712,900	7,712,900
Capital International Investors	[2025-06-30]	DFND	7,478,859	7,478,859
FMR LLC	[2025-06-30]	DFND	5,005,868	5,093,261
State Street Corp	[2025-06-30]	DFND	3,752,599	4,277,888
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	3,431,419	3,432,619
Geode Capital Management LLC	[2025-06-30]	DFND	3,340,707	3,340,707
Artisan Partners Limited Partnership	[2025-06-30]	SOLE	2,850,222	3,314,341
RTW Investments LP	[2025-06-30]	SOLE	3,084,558	3,084,558
Ameriprise Financial Inc	[2025-06-30]	DFND	0	2,957,973
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	2,859,452	2,859,452
Franklin Resources Inc	[2025-06-30]	DFND	2,346,693	2,350,133
Janus Henderson Group PLC	[2025-06-30]	DFND	0	2,293,142
Susquehanna International Group LLP	[2025-06-30]	OTR	212,222	2,293,022
Jane Street Group LLC	[2025-06-30]	DFND	2,090,722	2,236,822
Goldman Sachs Group Inc	[2025-06-30]	DFND	2,081,381	2,150,895
Millennium Management LLC	[2025-06-30]	SOLE	2,121,717	2,129,717
Holocene Advisors LP	[2025-06-30]	SOLE	2,016,806	2,016,806
Norges Bank	[2025-06-30]	SOLE	1,934,899	1,934,899
Invesco Ltd.	[2025-06-30]	DFND	0	1,896,333
Deep Track Capital LP	[2025-06-30]	SOLE	1,750,000	1,750,000
Citadel Advisors LLC	[2025-06-30]	DFND	1,737,977	1,737,977
William Blair Investment Management LLC	[2025-06-30]	SOLE	1,605,822	1,665,602
Integral Health Asset Management LLC	[2025-06-30]	SOLE	1,600,000	1,600,000
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	1,413,605	1,553,628
Orbis Allan Gray Ltd	[2025-06-30]	DFND	1,524,134	1,524,134
Clearbridge Investments LLC	[2025-06-30]	SOLE	1,424,444	1,424,562
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