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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	5,605,490.0	5,606,086.0
Capital International Investors	[2023-03-31]	DFND	3,389,607.0	3,389,607.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,934,638.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	889,644.0	2,480,765.0
BlackRock Inc.	[2023-03-31]	SOLE	2,429,041.0	2,469,481.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	386,166.0	2,449,052.0
Sofinnova Investments Inc	[2023-03-31]	SOLE	1,773,124.0	1,773,124.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	1,606,854.0
Viking Global Investors LP	[2023-03-31]	SOLE	1,501,074.0	1,501,074.0
State Street Corp	[2023-03-31]	DFND	923,834.0	996,535.0
Pivotal Bioventure Partners Investment Advisor LLC	[2023-03-31]	DFND	0.0	782,008.0
General Atlantic LP	[2023-03-31]	SOLE	716,158.0	716,158.0
AllianceBernstein LP	[2023-03-31]	DFND	581,087.0	626,190.0
Geode Capital Management LLC	[2023-03-31]	DFND	602,435.0	602,435.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	563,498.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	493,527.0	493,527.0
Lord Abbett & Co LLC	[2023-03-31]	SOLE	460,918.0	477,777.0
Susquehanna International Group LLP	[2023-03-31]	DFND	45,296.0	411,096.0
Avidity Partners Management LP	[2023-03-31]	SOLE	403,800.0	403,800.0
Bank of America Corp /DE/	[2023-03-31]	DFND	4,276.0	347,192.0
Eventide Asset Management LLC	[2023-03-31]	SOLE	339,898.0	339,898.0
Invesco Ltd.	[2023-03-31]	DFND	0.0	332,955.0
Brown Advisory Inc	[2023-03-31]	DFND	277,471.0	323,061.0
Northern Trust Corp	[2023-03-31]	DFND	18,682.0	291,892.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	251,088.0	251,088.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	245,314.0
First Light Asset Management LLC	[2023-03-31]	SOLE	243,675.0	243,675.0
Fiera Capital Corp	[2023-03-31]	OTR	214,333.0	235,968.0
Nan Fung Group Holdings Ltd	[2023-03-31]	DFND	225,688.0	225,688.0
Caption Management LLC	[2023-03-31]	SOLE	220,000.0	220,000.0
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