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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	2,900,392.0	2,900,392.0
Cormorant Asset Management LP	[2023-03-31]	DFND	2,353,141.0	2,353,141.0
Farallon Capital Management LLC	[2023-03-31]	OTR	1,560,500.0	1,560,500.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	207,298.0	1,464,774.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	1,250,000.0
Millennium Management LLC	[2023-03-31]	SOLE	1,047,705.0	1,047,705.0
ProSight Management LP	[2023-03-31]	SOLE	900,600.0	900,600.0
Integral Health Asset Management LLC	[2023-03-31]	SOLE	582,000.0	582,000.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	398,479.0
UBS OConnor LLC	[2023-03-31]	DFND	230,000.0	230,000.0
Woodline Partners LP	[2023-03-31]	SOLE	114,569.0	114,569.0
Geode Capital Management LLC	[2023-03-31]	DFND	81,906.0	81,906.0
CIBC Asset Management Inc	[2023-03-31]	SOLE	56,125.0	56,125.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	50,000.0	50,000.0
Bourgeon Capital Management LLC	[2023-03-31]	SOLE	49,855.0	49,855.0
TD Asset Management Inc	[2023-03-31]	SOLE	37,611.0	37,611.0
Laurion Capital Management LP	[2023-03-31]	SOLE	30,918.0	30,918.0
BlackRock Inc.	[2023-03-31]	SOLE	29,022.0	29,022.0
Manufacturers Life Insurance Company the	[2023-03-31]	DFND	28,249.0	28,249.0
Northern Trust Corp	[2023-03-31]	DFND	0.0	17,790.0
Tower Research Capital LLC (TRC)	[2023-03-31]	DFND	2,867.0	2,867.0
Citigroup Inc	[2023-03-31]	DFND	2,768.0	2,768.0
UBS Group AG	[2023-03-31]	SOLE	528.0	528.0
Tower Research Capital LLC (TRC)	[2023-03-31]	OTR	170.0	170.0
Morgan Stanley	[2023-03-31]	DFND	169.0	169.0
Wells Fargo & Company/MN	[2023-03-31]	DFND	94.0	94.0
Concourse Financial Group Securities Inc	[2023-03-31]	SOLE	0.0	0.0
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