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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	4,178,823	4,178,823
Alpha Wave Global LP	[2025-06-30]	SOLE	3,612,211	3,612,211
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	1,717,066	1,717,066
BlackRock, Inc.	[2025-06-30]	SOLE	1,400,228	1,432,461
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,258,903
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,122,738	1,122,738
72 Investment Holdings, LLC	[2025-06-30]	DFND	0	1,017,751
Sectoral Asset Management Inc	[2025-06-30]	SOLE	977,245	977,245
Tang Capital Management LLC	[2025-06-30]	OTR	0	897,616
UBS Group AG	[2025-06-30]	DFND	881,247	881,481
RTW Investments LP	[2025-06-30]	SOLE	863,389	863,389
Point72 Asset Management LP	[2025-06-30]	DFND	0	618,142
Morgan Stanley	[2025-06-30]	DFND	571,237	585,355
Geode Capital Management LLC	[2025-06-30]	DFND	416,122	416,122
State Street Corp	[2025-06-30]	DFND	351,001	375,728
Ally Bridge Group NY LLC	[2025-06-30]	SOLE	343,322	343,322
Samsara Biocapital LLC	[2025-06-30]	SOLE	343,012	343,012
Saturn V Capital Management LP	[2025-06-30]	SOLE	342,312	342,312
Invesco Ltd.	[2025-06-30]	DFND	0	266,680
Summit Partners Public Asset Management LLC	[2025-06-30]	SOLE	124,915	240,000
Alyeska Investment Group LP	[2025-06-30]	SOLE	217,113	217,113
Scoggin Management LP	[2025-06-30]	DFND	200,000	200,000
Susquehanna International Group LLP	[2025-06-30]	OTR	22,185	196,685
Stempoint Capital LP	[2025-06-30]	SOLE	163,153	183,912
Granahan Investment Management LLC	[2025-06-30]	SOLE	166,712	183,252
Nuveen, LLC	[2025-06-30]	DFND	178,214	178,214
Caption Management LLC	[2025-06-30]	SOLE	175,000	175,000
Candriam S.C.A.	[2025-06-30]	SOLE	171,274	171,274
Northern Trust Corp	[2025-06-30]	DFND	168,011	168,011
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	142,112	142,112
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