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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Artal Group S.A.	[2025-06-30]	DFND	136,180,481	136,180,481
Siren, L.L.C.	[2025-06-30]	DFND	38,918,903	38,918,903
FMR LLC	[2025-06-30]	DFND	38,112,677	38,137,535
Vanguard Group Inc	[2025-06-30]	SOLE	0	8,779,831
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	4,576,152	4,576,152
BlackRock, Inc.	[2025-06-30]	SOLE	3,354,669	3,354,669
Sessa Capital IM LP	[2025-06-30]	SOLE	3,000,000	3,000,000
GSA Capital Partners LLP	[2025-06-30]	SOLE	2,830,659	2,830,659
CIBC Private Wealth Group LLC	[2025-06-30]	SOLE	2,450,400	2,450,400
Geode Capital Management LLC	[2025-06-30]	DFND	2,377,694	2,377,694
Millennium Management LLC	[2025-06-30]	SOLE	1,643,264	1,643,264
AQR Capital Management LLC	[2025-06-30]	DFND	1,369,650	1,369,650
Susquehanna International Group LLP	[2025-06-30]	OTR	755,652	964,952
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	883,227	883,227
Jane Street Group LLC	[2025-06-30]	DFND	804,667	867,267
State Street Corp	[2025-06-30]	DFND	818,621	818,621
Hennion & Walsh Asset Management Inc	[2025-06-30]	SOLE	793,400	793,400
Royal Bank of Canada	[2025-06-30]	DFND	769,030	769,030
Monaco Asset Management SAM	[2025-06-30]	SOLE	531,600	531,600
HRT Financial LP	[2025-06-30]	DFND	488,468	488,468
Wellington Management Group LLP	[2025-06-30]	DFND	0	486,674
Invesco Ltd.	[2025-06-30]	DFND	0	420,700
Northern Trust Corp	[2025-06-30]	DFND	415,943	416,372
Two Sigma Investments LP	[2025-06-30]	SOLE	403,922	403,922
UBS Group AG	[2025-06-30]	DFND	390,924	400,732
Group One Trading LLC	[2025-06-30]	SOLE	346,752	346,752
Compagnie Lombard Odier SCmA	[2025-06-30]	DFND	330,000	330,000
Goldman Sachs Group Inc	[2025-06-30]	DFND	325,745	325,746
Citadel Advisors LLC	[2025-06-30]	DFND	275,600	275,600
Cerity Partners LLC	[2025-06-30]	SOLE	95,512	206,279
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