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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Arch Venture Management LLC	[2025-06-30]	SOLE	0	1,820,634
MWG Management Ltd.	[2025-06-30]	DFND	1,008,116	1,008,116
Foresite Capital Management IV, LLC	[2025-06-30]	SOLE	800,399	800,399
Orland Properties Ltd	[2025-06-30]	DFND	754,698	754,698
Decheng Capital LLC	[2025-06-30]	SOLE	595,466	595,466
Almitas Capital LLC	[2025-06-30]	SOLE	579,997	579,997
venBio Partners LLC	[2025-06-30]	SOLE	473,479	473,479
Vanguard Group Inc	[2025-06-30]	SOLE	0	439,787
Foresite Capital Management V, LLC	[2025-06-30]	SOLE	406,652	406,652
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	296,131	296,131
Alphabet Inc.	[2025-06-30]	DFND	0	293,256
Citadel Advisors LLC	[2025-06-30]	DFND	287,273	287,273
HSG Holding Ltd	[2025-06-30]	DFND	152,299	152,299
BlackRock, Inc.	[2025-06-30]	SOLE	144,859	144,859
Geode Capital Management LLC	[2025-06-30]	DFND	103,270	103,270
RBF Capital, LLC	[2025-06-30]	SOLE	100,000	100,000
Woodline Partners LP	[2025-06-30]	SOLE	98,425	98,425
MIC Capital Management UK LLP	[2025-06-30]	SOLE	87,028	87,028
Renaissance Technologies LLC	[2025-06-30]	SOLE	67,190	67,190
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	61,503	61,503
Millennium Management LLC	[2025-06-30]	SOLE	52,229	52,229
OrbiMed Advisors LLC	[2025-06-30]	SOLE	51,727	51,727
TD Asset Management Inc	[2025-06-30]	SOLE	50,232	50,232
Ikarian Capital LLC	[2025-06-30]	SOLE	43,799	43,799
Takeda Pharmaceutical Co Ltd	[2025-06-30]	DFND	41,165	41,165
Johnson & Johnson	[2025-06-30]	DFND	0	41,165
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	39,621	39,621
State Street Corp	[2025-06-30]	DFND	33,847	33,847
Canada Pension Plan Investment Board	[2025-06-30]	SOLE	29,411	29,411
Walleye Capital LLC	[2025-06-30]	SOLE	29,230	29,230
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