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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Janus Henderson Group PLC	[2025-06-30]	DFND	0	17,688,592
Rubric Capital Management LP	[2025-06-30]	SOLE	15,307,347	15,307,347
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	9,440,112	9,440,112
Mangrove Partners IM LLC	[2025-06-30]	SOLE	8,636,485	8,636,485
Deerfield Management Company LP	[2025-06-30]	DFND	6,710,429	6,710,429
Alkeon Capital Management LLC	[2025-06-30]	SOLE	4,698,100	4,698,100
Rock Springs Capital Management LP	[2025-06-30]	SOLE	4,465,292	4,465,292
683 Capital Management LLC	[2025-06-30]	DFND	4,350,000	4,350,000
Clearline Capital LP	[2025-06-30]	SOLE	3,618,163	3,618,163
Goldman Sachs Group Inc	[2025-06-30]	DFND	3,090,068	3,090,068
Aberdeen Group plc	[2025-06-30]	DFND	3,028,872	3,028,872
Tejara Capital Ltd	[2025-06-30]	SOLE	2,430,437	2,430,437
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,480,471	1,480,471
FMR LLC	[2025-06-30]	DFND	1,478,500	1,478,500
Diadema Partners LP	[2025-06-30]	SOLE	1,357,000	1,357,000
Millennium Management LLC	[2025-06-30]	SOLE	595,673	1,037,373
Citadel Advisors LLC	[2025-06-30]	DFND	922,659	922,659
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	909,640	909,640
Morgan Stanley	[2025-06-30]	DFND	783,358	785,377
Marshall Wace LLP	[2025-06-30]	OTR	0	767,744
Atle Fund Management AB	[2025-06-30]	SOLE	2,072,882	764,901
Two Sigma Investments LP	[2025-06-30]	SOLE	659,158	659,158
Caption Management LLC	[2025-06-30]	SOLE	635,099	635,099
Susquehanna International Group LLP	[2025-06-30]	OTR	361,542	606,742
Soleus Capital Management LP	[2025-06-30]	SOLE	599,711	599,711
Jane Street Group LLC	[2025-06-30]	DFND	469,141	496,141
Artia Global Partners LP	[2025-06-30]	SOLE	475,361	475,361
BlackRock, Inc.	[2025-06-30]	SOLE	451,007	455,365
Hudson Bay Capital Management LP	[2025-06-30]	SOLE	450,000	450,000
Bank of America Corp /DE/	[2025-06-30]	DFND	0	438,661
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