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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	15,758,330	15,758,330
Alphabet Inc.	[2025-06-30]	DFND	0	4,961,744
Softbank Group Corp	[2025-06-30]	DFND	4,819,884	4,819,884
MIC Capital Management UK LLP	[2025-06-30]	SOLE	4,539,540	4,539,540
VR Adviser LLC	[2025-06-30]	SOLE	3,750,662	3,750,662
Wellington Management Group LLP	[2025-06-30]	DFND	0	3,427,432
Janus Henderson Group PLC	[2025-06-30]	DFND	0	3,387,963
Alpha Wave Global LP	[2025-06-30]	SOLE	2,384,050	2,384,050
Viking Global Investors LP	[2025-06-30]	SOLE	1,616,612	1,616,612
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,454,534
AllianceBernstein LP	[2025-06-30]	DFND	1,293,096	1,421,359
BlackRock, Inc.	[2025-06-30]	SOLE	1,200,118	1,237,125
Deep Track Capital LP	[2025-06-30]	SOLE	1,094,408	1,094,408
RA Capital Management LP	[2025-06-30]	SOLE	675,525	675,525
State Street Corp	[2025-06-30]	DFND	572,940	600,203
Geode Capital Management LLC	[2025-06-30]	DFND	466,955	466,955
Woodline Partners LP	[2025-06-30]	SOLE	400,785	400,785
Cormorant Asset Management LP	[2025-06-30]	DFND	400,000	400,000
Eventide Asset Management LLC	[2025-06-30]	SOLE	396,160	396,160
Royce & Associates LP	[2025-06-30]	SOLE	331,280	331,280
Jennison Associates LLC	[2025-06-30]	DFND	312,290	312,290
American Century Companies Inc	[2025-06-30]	DFND	241,138	287,674
EcoR1 Capital LLC	[2025-06-30]	SOLE	271,529	271,529
Citadel Advisors LLC	[2025-06-30]	DFND	266,218	266,218
Massachusetts Financial Services Co /MA/	[2025-06-30]	SOLE	253,712	253,712
SilverArc Capital Management LLC	[2025-06-30]	SOLE	207,581	207,581
Logos Global Management LP	[2025-06-30]	SOLE	200,000	200,000
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	136,406	136,406
Northern Trust Corp	[2025-06-30]	DFND	133,030	133,030
AXA Sa	[2025-06-30]	DFND	114,405	114,405
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