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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RTW Investments LP	[2025-06-30]	SOLE	8,306,062	8,306,062
Perceptive Advisors LLC	[2025-06-30]	SOLE	4,592,556	4,592,556
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,147,259
BlackRock, Inc.	[2025-06-30]	SOLE	681,349	681,349
Knoll Capital Management, LLC	[2025-06-30]	SOLE	169,824	455,128
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	430,818	430,818
Millennium Management LLC	[2025-06-30]	SOLE	409,674	409,674
Geode Capital Management LLC	[2025-06-30]	DFND	302,082	302,082
Renaissance Technologies LLC	[2025-06-30]	SOLE	169,400	169,400
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	138,591	138,591
State Street Corp	[2025-06-30]	DFND	130,133	130,133
Susquehanna International Group LLP	[2025-06-30]	OTR	118,558	118,558
Northern Trust Corp	[2025-06-30]	DFND	100,435	100,435
Knott David M Jr	[2025-06-30]	DFND	100,000	100,000
Goldman Sachs Group Inc	[2025-06-30]	DFND	96,841	96,841
TD Asset Management Inc	[2025-06-30]	SOLE	92,678	92,678
IFP Advisors, Inc	[2025-06-30]	SOLE	85,358	85,358
Hightower Advisors LLC	[2025-06-30]	SOLE	66,500	66,500
Lasry Marc	[2025-06-30]	DFND	60,869	60,869
Holos Integrated Wealth LLC	[2025-06-30]	SOLE	51,595	51,595
Marshall Wace LLP	[2025-06-30]	OTR	0	49,465
Citadel Advisors LLC	[2025-06-30]	DFND	49,441	49,441
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	45,447	45,447
Newedge Advisors LLC	[2025-06-30]	SOLE	0	44,083
Manufacturers Life Insurance Company the	[2025-06-30]	DFND	32,518	32,518
Squarepoint Ops LLC	[2025-06-30]	DFND	0	28,221
HRT Financial LP	[2025-06-30]	DFND	28,217	28,217
Tower Research Capital LLC (TRC)	[2025-06-30]	DFND	27,922	27,922
UBS Group AG	[2025-06-30]	DFND	26,139	26,139
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	25,000	25,000
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