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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Pivotal Bioventure Partners Investment Advisor LLC	[2025-06-30]	DFND	0	2,300,774
Aberdeen Group plc	[2025-06-30]	DFND	1,253,119	1,253,119
Nan Fung Group Holdings Ltd	[2025-06-30]	DFND	514,702	514,702
SR One Capital Management LP	[2025-06-30]	SOLE	322,500	322,500
Alyeska Investment Group LP	[2025-06-30]	SOLE	131,332	131,332
UBS Group AG	[2025-06-30]	DFND	121,473	126,515
Acuta Capital Partners LLC	[2025-06-30]	SOLE	106,718	106,718
Compagnie Lombard Odier SCmA	[2025-06-30]	DFND	97,000	97,000
Woodline Partners LP	[2025-06-30]	SOLE	50,568	50,568
Bank of America Corp /DE/	[2025-06-30]	DFND	0	40,512
Geode Capital Management LLC	[2025-06-30]	DFND	29,436	29,436
Northern Trust Corp	[2025-06-30]	DFND	23,319	23,319
Marshall Wace LLP	[2025-06-30]	OTR	0	20,253
Bosun Asset Management LLC	[2025-06-30]	SOLE	19,472	19,472
Polen Capital Management LLC	[2025-06-30]	SOLE	19,472	19,472
Kestra Private Wealth Services LLC	[2025-06-30]	SOLE	0	15,236
State Street Corp	[2025-06-30]	DFND	12,781	12,781
Morgan Stanley	[2025-06-30]	DFND	11,158	12,158
Bellevue Group AG	[2025-06-30]	DFND	9,700	9,700
Royal Bank of Canada	[2025-06-30]	SOLE	45	45
Raymond James Financial Inc	[2025-06-30]	DFND	0	26
Dupont Capital Management Corp	[2025-06-30]	SOLE	4	4
SBI Securities Co., Ltd.	[2025-06-30]	DFND	4	4
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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