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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2025-06-30]	SOLE	8,799,053	8,799,053
PRIMECAP Management Co/CA/	[2025-06-30]	SOLE	4,990,279	5,088,279
Capital International Investors	[2025-06-30]	DFND	4,858,656	4,885,006
FMR LLC	[2025-06-30]	DFND	3,423,647	3,449,793
HHLR Advisors Ltd	[2025-06-30]	OTR	0	1,034,306
Temasek Holdings (Private) Ltd	[2025-06-30]	DFND	1,010,465	1,010,465
Citadel Advisors LLC	[2025-06-30]	DFND	556,956	556,956
Siren, L.L.C.	[2025-06-30]	DFND	509,990	509,990
BlackRock, Inc.	[2025-06-30]	SOLE	472,886	501,189
Marshall Wace LLP	[2025-06-30]	OTR	0	467,590
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	347,787	347,787
Capital International, Inc./CA/	[2025-06-30]	DFND	323,491	345,559
Nuveen, LLC	[2025-06-30]	DFND	344,207	344,207
Baird Financial Group, Inc.	[2025-06-30]	DFND	397	342,442
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	294,920	302,999
Candriam S.C.A.	[2025-06-30]	SOLE	280,286	280,286
Bank of America Corp /DE/	[2025-06-30]	DFND	2,542	279,493
Artisan Partners Limited Partnership	[2025-06-30]	SOLE	244,811	270,153
Morgan Stanley	[2025-06-30]	DFND	219,955	268,474
Man Group plc	[2025-06-30]	DFND	118,185	243,861
Public Investment Fund	[2025-06-30]	SOLE	227,177	227,177
Millennium Management LLC	[2025-06-30]	SOLE	201,355	201,355
Driehaus Capital Management LLC	[2025-06-30]	SOLE	154,646	198,203
UBS Group AG	[2025-06-30]	DFND	180,960	181,515
M&G Plc	[2025-06-30]	SOLE	148,924	170,202
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	159,800	159,800
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	158,372
Capital Group Private Client Services Inc	[2025-06-30]	DFND	147,670	148,613
First Trust Advisors LP	[2025-06-30]	SOLE	140,339	140,339
Capital International SARL	[2025-06-30]	DFND	126,460	133,924
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