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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
General Atlantic LP	[2025-06-30]	SOLE	7,531,252	7,531,252
FMR LLC	[2025-06-30]	DFND	5,422,393	5,422,393
Foresite Capital Management IV, LLC	[2025-06-30]	SOLE	4,410,581	4,410,581
venBio Partners LLC	[2025-06-30]	SOLE	4,289,304	4,289,304
Viking Global Investors LP	[2025-06-30]	SOLE	3,653,310	3,653,310
Bain Capital Life Sciences Investors, LLC	[2025-06-30]	SOLE	3,303,381	3,303,381
VR Adviser LLC	[2025-06-30]	SOLE	2,047,620	2,047,620
Deerfield Management Company LP	[2025-06-30]	DFND	2,017,464	2,017,464
Commodore Capital LP	[2025-06-30]	SOLE	1,911,433	1,911,433
Novo Holdings A/S	[2025-06-30]	SOLE	1,725,000	1,725,000
Cormorant Asset Management LP	[2025-06-30]	DFND	1,454,660	1,454,660
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	1,062,911	1,062,911
5AM Venture Management LLC	[2025-06-30]	SOLE	797,600	797,600
Soleus Capital Management LP	[2025-06-30]	SOLE	732,968	732,968
Octagon Capital Advisors LP	[2025-06-30]	SOLE	672,595	672,595
Rock Springs Capital Management LP	[2025-06-30]	SOLE	623,402	623,402
Sofinnova Investments Inc	[2025-06-30]	SOLE	585,532	585,532
Sphera Funds Management Ltd	[2025-06-30]	DFND	309,931	309,931
Patient Square Capital LP	[2025-06-30]	SOLE	244,283	244,283
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	223,627	223,627
BlackRock, Inc.	[2025-06-30]	SOLE	193,195	201,089
TFG Asset Management GP Ltd	[2025-06-30]	DFND	0	188,100
TD Asset Management Inc	[2025-06-30]	SOLE	99,510	99,510
Northern Trust Corp	[2025-06-30]	DFND	95,269	95,269
State Street Corp	[2025-06-30]	DFND	79,373	93,673
Morgan Stanley	[2025-06-30]	DFND	36,043	59,772
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	SOLE	8,531	55,377
Geode Capital Management LLC	[2025-06-30]	DFND	54,102	54,102
Manufacturers Life Insurance Company the	[2025-06-30]	DFND	48,857	48,857
Point72 Asset Management LP	[2025-06-30]	DFND	0	37,612
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