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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Alphabet Inc.	[2025-06-30]	DFND	0	15,062,498
BlackRock, Inc.	[2025-06-30]	SOLE	4,382,699	4,485,828
FMR LLC	[2025-06-30]	DFND	3,738,166	3,744,427
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,586,077
ARK Investment Management LLC	[2025-06-30]	SOLE	2,322,669	2,322,669
Redmile Group LLC	[2025-06-30]	SOLE	2,074,350	2,074,350
MWG Management Ltd.	[2025-06-30]	DFND	1,792,210	1,792,210
Sumitomo Mitsui Trust Group, Inc.	[2025-06-30]	DFND	1,594,518	1,594,518
Nikko Asset Management Americas Inc	[2025-06-30]	SOLE	1,245,482	1,589,117
Casdin Capital LLC	[2025-06-30]	SOLE	1,567,175	1,567,175
Geode Capital Management LLC	[2025-06-30]	DFND	1,510,749	1,510,749
State Street Corp	[2025-06-30]	DFND	1,179,337	1,239,337
Greenwich Wealth Management LLC	[2025-06-30]	SOLE	846,201	846,201
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	818,518	818,518
Citadel Advisors LLC	[2025-06-30]	DFND	766,308	766,308
Farallon Capital Management LLC	[2025-06-30]	OTR	750,000	750,000
Susquehanna International Group LLP	[2025-06-30]	OTR	482,728	609,828
Morgan Stanley	[2025-06-30]	DFND	551,734	587,676
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	518,628	518,628
Northern Trust Corp	[2025-06-30]	DFND	503,250	503,250
Moore Capital Management LP	[2025-06-30]	SOLE	500,000	500,000
AQR Capital Management LLC	[2025-06-30]	DFND	408,968	408,968
Fred Alger Management LLC	[2025-06-30]	SOLE	383,194	383,194
Bollard Group LLC	[2025-06-30]	DFND	0	361,136
Two Sigma Investments LP	[2025-06-30]	SOLE	258,423	258,423
Renaissance Technologies LLC	[2025-06-30]	SOLE	223,400	223,400
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	214,800	214,800
Chelsea Counsel Co	[2025-06-30]	SOLE	200,420	208,210
Nuveen, LLC	[2025-06-30]	DFND	207,894	207,894
Goldman Sachs Group Inc	[2025-06-30]	DFND	206,953	207,008
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