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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Suvretta Capital Management LLC	[2025-06-30]	SOLE	12,341,266	12,341,266
Morgan Stanley	[2025-06-30]	DFND	5,705,558	5,987,541
Bleichroeder LP	[2025-06-30]	SOLE	2,000,000	2,000,000
BlackRock, Inc.	[2025-06-30]	SOLE	1,756,864	1,764,607
JPMorgan Chase & Co	[2025-06-30]	DFND	1,668,642	1,668,642
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,533,794
Geode Capital Management LLC	[2025-06-30]	DFND	1,012,120	1,012,120
Brown University	[2025-06-30]	SOLE	1,000,000	1,000,000
Hennion & Walsh Asset Management Inc	[2025-06-30]	SOLE	936,826	936,826
Bank of America Corp /DE/	[2025-06-30]	DFND	0	846,154
Jane Street Group LLC	[2025-06-30]	DFND	591,688	591,688
Goldman Sachs Group Inc	[2025-06-30]	DFND	580,823	580,823
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	559,794	559,794
GSA Capital Partners LLP	[2025-06-30]	SOLE	510,615	510,615
UBS Group AG	[2025-06-30]	DFND	472,864	475,047
Renaissance Technologies LLC	[2025-06-30]	SOLE	411,645	411,645
State Street Corp	[2025-06-30]	DFND	353,607	353,607
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	351,622	351,622
Northern Trust Corp	[2025-06-30]	DFND	251,386	251,386
HRT Financial LP	[2025-06-30]	DFND	215,370	215,370
AQR Capital Management LLC	[2025-06-30]	DFND	193,288	193,288
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	176,452
Susquehanna International Group LLP	[2025-06-30]	OTR	121,323	121,323
Royal Bank of Canada	[2025-06-30]	DFND	119,571	119,571
Jain Global LLC	[2025-06-30]	SOLE	112,406	112,406
Citadel Advisors LLC	[2025-06-30]	DFND	111,000	111,000
Two Sigma Investments LP	[2025-06-30]	SOLE	70,699	70,699
Point72 Asia (Singapore) Pte. Ltd.	[2025-06-30]	DFND	0	66,281
FMR LLC	[2025-06-30]	DFND	56,275	65,575
SG Americas Securities LLC	[2025-06-30]	SOLE	61,870	61,870
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