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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BVF Inc/IL	[2023-03-31]	DFND	0.0	3,526,729.0
Cormorant Asset Management LP	[2023-03-31]	DFND	2,978,660.0	2,978,660.0
Samsara Biocapital LLC	[2023-03-31]	SOLE	2,260,652.0	2,260,652.0
Boxer Capital, LLC	[2023-03-31]	OTR	2,147,212.0	2,147,212.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	2,123,282.0	2,123,282.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	1,648,215.0	1,648,215.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	1,336,722.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	872,190.0
GMT Capital Corp	[2023-03-31]	SOLE	824,865.0	824,865.0
Sectoral Asset Management Inc	[2023-03-31]	SOLE	221,456.0	484,928.0
FMR LLC	[2023-03-31]	DFND	349,069.0	349,069.0
Susquehanna International Group LLP	[2023-03-31]	DFND	184,981.0	341,681.0
Laurion Capital Management LP	[2023-03-31]	SOLE	313,200.0	313,200.0
Ghost Tree Capital LLC	[2023-03-31]	SOLE	250,000.0	250,000.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	227,393.0	227,393.0
Alyeska Investment Group LP	[2023-03-31]	SOLE	200,000.0	200,000.0
Geode Capital Management LLC	[2023-03-31]	DFND	161,893.0	161,893.0
Woodline Partners LP	[2023-03-31]	SOLE	119,700.0	119,700.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	85,082.0	85,082.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	79,326.0
BlackRock Inc.	[2023-03-31]	SOLE	75,493.0	75,493.0
UBS OConnor LLC	[2023-03-31]	DFND	67,842.0	67,842.0
Victory Capital Management Inc	[2023-03-31]	SOLE	56,620.0	56,620.0
State Street Corp	[2023-03-31]	DFND	55,063.0	55,063.0
Two Sigma Investments LP	[2023-03-31]	SOLE	49,202.0	49,202.0
Millennium Management LLC	[2023-03-31]	SOLE	44,840.0	44,840.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	41,100.0	41,100.0
Citigroup Inc	[2023-03-31]	DFND	40,742.0	40,742.0
J Goldman & Co LP	[2023-03-31]	SOLE	40,500.0	40,500.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	40,309.0	40,309.0
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