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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
TRV GP V LLC	[2025-06-30]	SOLE	7,135,233	7,135,233
FMR LLC	[2025-06-30]	DFND	5,474,633	5,474,633
Arch Venture Management LLC	[2025-06-30]	SOLE	0	3,728,738
Cormorant Asset Management LP	[2025-06-30]	DFND	2,940,921	2,940,921
Capital International Investors	[2025-06-30]	DFND	2,602,529	2,602,529
Johnson & Johnson	[2025-06-30]	DFND	0	2,498,051
Sofinnova Investments Inc	[2025-06-30]	SOLE	1,995,594	1,995,594
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,235,035	1,235,035
BlackRock, Inc.	[2025-06-30]	SOLE	1,189,642	1,219,201
AllianceBernstein LP	[2025-06-30]	DFND	1,122,124	1,154,688
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,096,839
TRV GP VI LLC	[2025-06-30]	SOLE	969,218	969,218
Baker Bros Advisors LP	[2025-06-30]	SOLE	550,090	550,090
Siren, L.L.C.	[2025-06-30]	DFND	378,469	378,469
Geode Capital Management LLC	[2025-06-30]	DFND	333,159	333,159
State Street Corp	[2025-06-30]	DFND	279,608	298,708
UBS Group AG	[2025-06-30]	DFND	273,507	273,507
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	SOLE	243,880	243,880
Logos Global Management LP	[2025-06-30]	SOLE	208,910	208,910
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	199,643	199,643
TD Asset Management Inc	[2025-06-30]	SOLE	196,870	196,870
Ensign Peak Advisors, Inc	[2025-06-30]	SOLE	194,200	194,200
Woodline Partners LP	[2025-06-30]	SOLE	185,028	185,028
Sectoral Asset Management Inc	[2025-06-30]	SOLE	0	179,860
Driehaus Capital Management LLC	[2025-06-30]	SOLE	131,340	131,340
Northern Trust Corp	[2025-06-30]	DFND	113,528	113,784
Manufacturers Life Insurance Company the	[2025-06-30]	DFND	100,424	100,424
Deep Track Capital LP	[2025-06-30]	SOLE	98,237	98,237
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	93,497	93,497
Barclays PLC	[2025-06-30]	SOLE	71,108	71,108
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