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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Gilead Sciences Inc	[2025-06-30]	SOLE	31,424,760	31,424,760
BlackRock, Inc.	[2025-06-30]	SOLE	11,180,817	11,457,979
Vanguard Group Inc	[2025-06-30]	SOLE	0	6,417,307
Point72 Asset Management LP	[2025-06-30]	DFND	0	5,966,664
Woodline Partners LP	[2025-06-30]	SOLE	4,000,029	4,000,029
Suvretta Capital Management LLC	[2025-06-30]	SOLE	3,688,858	3,688,858
State Street Corp	[2025-06-30]	DFND	3,454,962	3,630,815
FMR LLC	[2025-06-30]	DFND	2,569,212	2,573,294
Balyasny Asset Management LP	[2025-06-30]	SOLE	1,870,312	1,870,312
Siren, L.L.C.	[2025-06-30]	DFND	1,612,077	1,612,077
Geode Capital Management LLC	[2025-06-30]	DFND	1,596,329	1,596,329
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	1,454,738	1,571,035
Morgan Stanley	[2025-06-30]	DFND	1,416,097	1,469,804
BNP Paribas Asset Management Holding S.A.	[2025-06-30]	DFND	0	1,395,726
Sofinnova Investments Inc	[2025-06-30]	SOLE	1,216,016	1,216,016
RA Capital Management LP	[2025-06-30]	SOLE	1,136,364	1,136,364
Wellington Management Group LLP	[2025-06-30]	DFND	0	936,021
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	742,932	805,305
Millennium Management LLC	[2025-06-30]	SOLE	780,088	780,088
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	776,683	776,742
Citadel Advisors LLC	[2025-06-30]	DFND	727,495	727,495
Northern Trust Corp	[2025-06-30]	DFND	654,268	655,580
Goldman Sachs Group Inc	[2025-06-30]	DFND	647,904	648,074
DAFNA Capital Management LLC	[2025-06-30]	SOLE	627,626	627,626
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	599,610	599,610
Jane Street Group LLC	[2025-06-30]	DFND	501,289	584,789
Bank of America Corp /DE/	[2025-06-30]	DFND	29,595	497,619
Granahan Investment Management LLC	[2025-06-30]	SOLE	439,327	490,613
Bank of New York Mellon Corp	[2025-06-30]	DFND	457,399	484,053
Hudson Bay Capital Management LP	[2025-06-30]	SOLE	430,000	430,000
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