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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Bain Capital Life Sciences Investors, LLC	[2025-06-30]	SOLE	8,434,560	8,434,560
ABG-WTT Global Life Science Capital Partners GP Ltd	[2025-06-30]	SOLE	1,848,296	1,848,296
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	1,037,668	1,037,668
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	913,443	913,443
Vanguard Group Inc	[2025-06-30]	SOLE	0	892,733
Advent International LP	[2025-06-30]	DFND	577,777	577,777
BlackRock, Inc.	[2025-06-30]	SOLE	476,817	476,817
Geode Capital Management LLC	[2025-06-30]	DFND	204,079	204,079
Informed Momentum Co LLC	[2025-06-30]	SOLE	170,105	170,105
Renaissance Technologies LLC	[2025-06-30]	SOLE	110,987	110,987
Essex Investment Management Co LLC	[2025-06-30]	SOLE	62,326	62,326
State Street Corp	[2025-06-30]	DFND	59,874	59,874
Susquehanna International Group LLP	[2025-06-30]	OTR	51,859	51,859
Northern Trust Corp	[2025-06-30]	DFND	48,559	48,559
Evernest Financial Advisors, LLC	[2025-06-30]	SOLE	44,000	44,000
XTX Topco Ltd	[2025-06-30]	DFND	41,800	41,800
Morgan Stanley	[2025-06-30]	DFND	16,042	36,223
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	33,271	33,271
Citadel Advisors LLC	[2025-06-30]	DFND	20,762	20,762
Mariner LLC	[2025-06-30]	SOLE	0	20,225
American Century Companies Inc	[2025-06-30]	DFND	16,922	16,922
Legato Capital Management LLC	[2025-06-30]	OTR	0	14,684
Vanguard Group Inc	[2025-06-30]	DFND	0	11,630
UBS Group AG	[2025-06-30]	DFND	8,693	8,693
Dimensional Fund Advisors LP	[2025-06-30]	DFND	0	7,116
Resources Management Corp /CT/ /ADV	[2025-06-30]	SOLE	500	500
Bank of America Corp /DE/	[2025-06-30]	DFND	0	177
JPMorgan Chase & Co	[2025-06-30]	DFND	109	109
Steward Partners Investment Advisory LLC	[2025-06-30]	SOLE	0	100
SBI Securities Co., Ltd.	[2025-06-30]	DFND	15	15
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