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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	7,081,381.0	7,083,533.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	5,714,423.0
BlackRock Inc.	[2023-03-31]	SOLE	4,813,662.0	4,929,567.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	4,882,871.0
Bellevue Group AG	[2023-03-31]	DFND	3,090,000.0	3,090,000.0
State Street Corp	[2023-03-31]	DFND	2,615,119.0	2,734,373.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	365,588.0	1,877,992.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	1,469,209.0	1,525,756.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	1,411,929.0
JPMorgan Chase & Co	[2023-03-31]	DFND	1,160,139.0	1,375,172.0
Ameriprise Financial Inc	[2023-03-31]	DFND	0.0	1,124,818.0
Boxer Capital, LLC	[2023-03-31]	OTR	1,094,000.0	1,094,000.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,040,245.0	1,040,245.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	902,917.0	946,138.0
Palo Alto Investors LP	[2023-03-31]	SOLE	859,517.0	859,517.0
Deutsche Bank AG	[2023-03-31]	DFND	718,166.0	777,413.0
Artal Group S.A.	[2023-03-31]	DFND	750,000.0	750,000.0
Manufacturers Life Insurance Company the	[2023-03-31]	DFND	624,671.0	624,671.0
Northern Trust Corp	[2023-03-31]	DFND	30,866.0	593,773.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	412,335.0	448,235.0
Susquehanna International Group LLP	[2023-03-31]	DFND	140,849.0	444,549.0
Fisher Asset Management LLC	[2023-03-31]	DFND	143,408.0	421,323.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	418,746.0
Finepoint Capital LP	[2023-03-31]	SOLE	388,865.0	388,865.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	385,417.0	385,417.0
Morgan Stanley	[2023-03-31]	DFND	260,622.0	372,652.0
Millennium Management LLC	[2023-03-31]	SOLE	366,663.0	366,663.0
Franklin Resources Inc	[2023-03-31]	DFND	300,274.0	301,723.0
Bank of America Corp /DE/	[2023-03-31]	DFND	8,238.0	284,001.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	211,575.0	248,632.0
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