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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Woodline Partners LP	[2025-06-30]	SOLE	2,552,536	2,552,536
Blue Owl Capital Holdings LP	[2025-06-30]	DFND	0	1,328,351
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,146,225
Baker Bros Advisors LP	[2025-06-30]	SOLE	952,996	952,996
HHLR Advisors Ltd	[2025-06-30]	OTR	0	724,800
Siren, L.L.C.	[2025-06-30]	DFND	724,771	724,771
UBS Group AG	[2025-06-30]	DFND	239,395	572,735
BlackRock, Inc.	[2025-06-30]	SOLE	483,083	483,083
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	412,841	412,841
Susquehanna International Group LLP	[2025-06-30]	OTR	141,407	369,807
Readystate Asset Management LP	[2025-06-30]	SOLE	269,193	269,193
Geode Capital Management LLC	[2025-06-30]	DFND	265,324	265,324
Raymond James Financial Inc	[2025-06-30]	DFND	0	264,675
Citadel Advisors LLC	[2025-06-30]	DFND	258,183	258,183
Jane Street Group LLC	[2025-06-30]	DFND	52,193	219,493
Morgan Stanley	[2025-06-30]	DFND	191,994	195,494
Millennium Management LLC	[2025-06-30]	SOLE	75,640	163,440
Jump Financial, LLC	[2025-06-30]	DFND	148,351	148,351
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	143,848	143,848
State Street Corp	[2025-06-30]	DFND	99,800	99,800
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	93,130	93,130
PFM Health Sciences LP	[2025-06-30]	DFND	0	90,000
Dumac Inc	[2025-06-30]	SOLE	75,000	75,000
HRT Financial LP	[2025-06-30]	DFND	69,909	69,909
Informed Momentum Co LLC	[2025-06-30]	SOLE	63,413	63,413
Northern Trust Corp	[2025-06-30]	DFND	52,297	52,297
American Century Companies Inc	[2025-06-30]	DFND	42,285	42,285
SilverArc Capital Management LLC	[2025-06-30]	SOLE	37,539	37,539
Hightower Advisors LLC	[2025-06-30]	SOLE	31,781	31,781
Renaissance Technologies LLC	[2025-06-30]	SOLE	30,900	30,900
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