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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
OrbiMed Advisors LLC	[2023-03-31]	SOLE	17,233,668.0	17,233,668.0
Foresite Capital Management V, LLC	[2023-03-31]	SOLE	3,585,346.0	3,585,346.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	2,248,194.0	2,248,194.0
Fairmount Funds Management LLC	[2023-03-31]	SOLE	1,865,671.0	1,865,671.0
Paradigm Biocapital Advisors LP	[2023-03-31]	SOLE	1,505,327.0	1,505,327.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	272,218.0	1,322,216.0
FMR LLC	[2023-03-31]	DFND	1,113,375.0	1,113,662.0
BlackRock Inc.	[2023-03-31]	SOLE	862,266.0	883,462.0
VR Adviser LLC	[2023-03-31]	SOLE	770,000.0	770,000.0
Lynx1 Capital Management LP	[2023-03-31]	OTR	0.0	761,258.0
Omega Fund Management LLC	[2023-03-31]	SOLE	711,479.0	711,479.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	687,709.0
Nextech Invest Ltd	[2023-03-31]	SOLE	611,310.0	611,310.0
Opaleye Management Inc	[2023-03-31]	SOLE	488,100.0	488,100.0
Citadel Advisors LLC	[2023-03-31]	DFND	484,386.0	484,386.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	460,728.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	437,329.0	437,329.0
Boxer Capital, LLC	[2023-03-31]	OTR	350,000.0	350,000.0
Geode Capital Management LLC	[2023-03-31]	DFND	327,870.0	327,870.0
Candriam SCA	[2023-03-31]	SOLE	323,793.0	323,793.0
State Street Corp	[2023-03-31]	DFND	279,964.0	296,864.0
Driehaus Capital Management LLC	[2023-03-31]	SOLE	226,201.0	226,201.0
Laurion Capital Management LP	[2023-03-31]	SOLE	179,619.0	179,619.0
Walleye Capital LLC	[2023-03-31]	SOLE	179,550.0	179,550.0
Bank of America Corp /DE/	[2023-03-31]	DFND	2,761.0	179,202.0
AllianceBernstein LP	[2023-03-31]	DFND	41,359.0	154,317.0
Woodline Partners LP	[2023-03-31]	SOLE	143,980.0	143,980.0
Ensign Peak Advisors, Inc	[2023-03-31]	SOLE	142,598.0	142,598.0
Northern Trust Corp	[2023-03-31]	DFND	649.0	133,460.0
DAFNA Capital Management LLC	[2023-03-31]	SOLE	131,025.0	131,025.0
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