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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	12,198,625	12,198,625
Alta Partners Management Company LP	[2025-06-30]	SOLE	4,080,296	4,080,296
Nextech Invest Ltd	[2025-06-30]	SOLE	4,055,861	4,055,861
BVF Inc/IL	[2025-06-30]	DFND	0	3,944,194
Canaan Partners XI LLC	[2025-06-30]	SOLE	3,608,109	3,608,109
Commodore Capital LP	[2025-06-30]	SOLE	3,100,000	3,100,000
TCG Crossover Management LLC	[2025-06-30]	SOLE	2,898,103	2,898,103
Janus Henderson Group PLC	[2025-06-30]	DFND	0	2,856,290
Vestal Point Capital LP	[2025-06-30]	SOLE	2,655,000	2,655,000
Kynam Capital Management LP	[2025-06-30]	SOLE	2,329,998	2,329,998
BlackRock, Inc.	[2025-06-30]	SOLE	1,832,743	1,893,328
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,383,590
Farallon Capital Management LLC	[2025-06-30]	OTR	1,143,818	1,143,818
5AM Venture Management LLC	[2025-06-30]	SOLE	939,298	939,298
SIO Capital Management LLC	[2025-06-30]	SOLE	810,274	810,274
OrbiMed Advisors LLC	[2025-06-30]	DFND	296,080	804,603
Balyasny Asset Management LP	[2025-06-30]	SOLE	583,386	583,386
Geode Capital Management LLC	[2025-06-30]	DFND	567,126	567,126
Marshall Wace LLP	[2025-06-30]	OTR	0	428,108
State Street Corp	[2025-06-30]	DFND	395,684	418,984
Millennium Management LLC	[2025-06-30]	SOLE	407,464	407,464
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	358,593	395,299
Morgan Stanley	[2025-06-30]	DFND	378,000	378,402
Bank of America Corp /DE/	[2025-06-30]	DFND	3,627	372,967
Walleye Capital LLC	[2025-06-30]	SOLE	370,408	370,408
Point72 Asset Management LP	[2025-06-30]	DFND	0	224,700
Citadel Advisors LLC	[2025-06-30]	DFND	216,136	216,136
Northern Trust Corp	[2025-06-30]	DFND	201,629	201,629
Caligan Partners LP	[2025-06-30]	SOLE	189,950	189,950
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	178,104	178,104
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